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Discriminated taste aversion and context: a progress report.

机译:歧视性的厌恶情绪和背景:进度报告。

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The research described here concerns the interaction between the environment (context), the organism, and the effects of opiates, focusing on how conditioning and contextual cues affect drug controlled behaviors. This analysis applies the powerful tool of drug discrimination to a respondent conditioning procedure (discriminated taste aversion, DTA). Data show that the use of DTA is feasible in that it is sensitive to morphine dose and saccharin concentration. Swifter control over DTA was achieved by increasing the LiCl dose (UCS magnitude). It is also clear that morphine alone can serve as a discriminative stimulus not requiring saccharin as a contextual element (which has been the case for most DTA studies to date), or saccharin being part of a compounded stimulus. Pharmacological specificity was demonstrated in substitution tests with delta-9-tetrahydrocannabinol. This research continues a systematic experimental analysis of the interaction between drug-controlled behavior and context.
机译:这里描述的研究涉及环境(环境),生物体和阿片类药物的影响之间的相互作用,重点在于调节和上下文提示如何影响药物控制行为。该分析将强大的药物识别工具应用于响应者调节程序(歧视性味觉厌恶,DTA)。数据表明,DTA的使用是可行的,因为它对吗啡剂量和糖精浓度敏感。通过增加LiCl剂量(UCS量级)可以更快地控制DTA。同样清楚的是,单独的吗啡可以用作区分性刺激,不需要糖精作为背景元素(迄今为止,大多数DTA研究就是这种情况),或者糖精是复合刺激的一部分。在用delta-9-四氢大麻酚的替代测试中证实了药理学特异性。这项研究继续对药物控制的行为与环境之间的相互作用进行系统的实验分析。

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