• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Effects of withdrawal from an escalating dose schedule of d-amphetamine on sexual behavior in the male rat.
【24h】

Effects of withdrawal from an escalating dose schedule of d-amphetamine on sexual behavior in the male rat.

机译：d-苯异丙胺逐步停用剂量表对雄性大鼠性行为的影响。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The present study sought to determine the effect of withdrawal from an escalating dose schedule of d-amphetamine on sexual behavior in male rats. Tests were conducted every 5 days until stable levels of sexual behavior were obtained. With repeated testing, male rats displayed an increase in their exploration of the testing chambers prior to the introduction of an estrous female. Half of the male rats were then subjected to a 4-day escalating dose schedule of d-amphetamine administration (1-12 mg/kg), while half received vehicle. Twelve hours after the final drug injection, subjects were tested for sexual behavior. Withdrawal from the drug was associated with decrements in several motivational components of sexual behavior, including decreased anticipatory locomotor and increased postejaculatory intervals, while consummatory measures remained largely unaffected. This pattern of sexual deficits resembles those seen in human depressive disorders, and therefore, provides additional support for the use of psychostimulant withdrawal as a rodent model of depression.
机译：本研究试图确定从不断增加的d-苯异丙胺剂量表中退出对雄性大鼠性行为的影响。每5天进行一次测试，直到获得稳定的性行为水平。通过反复测试，雄性大鼠在引入发情雌性之前对试验室的探索性增加。然后将一半的雄性大鼠接受d-苯丙胺给药的4天递增剂量方案（1-12 mg / kg），而另一半接受媒介物。最后一次药物注射后十二小时，对受试者进行性行为测试。撤药与性行为的一些动机组成部分减少有关，包括预期的运动减少和射精后间隔的增加，而完善的措施仍未受影响。这种性缺陷的模式类似于在人类抑郁症中所见的性缺陷，因此为使用精神刺激药戒断作为啮齿类动物抑郁模型提供了额外的支持。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号