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Sensitization of stereotyped behavior to amphetamine is context and response dependent.

机译：刻板印象行为对苯丙胺的敏化取决于上下文和反应。

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摘要

The present study was designed to determine whether the environmental context in which amphetamine is administered plays a role in the development of sensitization to the stereotyped behavioral effects of amphetamine in mice. In male CF-1 mice, the dose-response curve for stereotyped behavior elicited by amphetamine was shifted 1.9-fold to the left 48 h after pretreatment with 14 mg/kg amphetamine. Behavioral sensitization only developed in mice that were pretreated in the same or a similar environment as that of the test environment. In addition, when mice were placed in an environment that attenuated the acute expression of stereotyped behavior elicited by the pretreatment dose of amphetamine, sensitization never developed. A further experiment showed that 96% of the mice that expressed stereotypy after the ED50 pretreatment dose of 10 mg/kg amphetamine showed a stereotyped behavioral response to the lesser dose of 7 mg/kg 48 h later, indicating sensitization. In contrast, mice that did not express stereotypy after the ED50 dose of amphetamine failed to show a significant stereotyped behavioral response to amphetamine challenge compared to vehicle-pretreated controls. Therefore, the results indicate that preexposure to a single high dose of amphetamine produces context- and response-dependent sensitization to amphetamine-induced stereotyped behavior.
机译：本研究旨在确定安非他命的环境环境是否在对苯丙胺在小鼠中的定型行为效应致敏的发展中起作用。在雄性CF-1小鼠中，用14 mg / kg安非他明预处理后，苯丙胺引起的刻板印象行为的剂量反应曲线向左移动1.9倍，向左移动1.9倍。行为敏化仅在与测试环境相同或相似的环境中进行过预处理的小鼠中发生。另外，当将小鼠放置在减弱了苯丙胺的预处理剂量引起的刻板印象行为的急性表达的环境中时，敏化作用从未发生。进一步的实验表明，在ED50预处理剂量10 mg / kg苯丙胺后表达刻板印象的96％的小鼠在48小时后对7 mg / kg的较小剂量表现出定型的行为反应，表明有致敏性。相比之下，与媒介物预处理的对照组相比，在ED50剂量的苯丙胺后未表达刻板印象的小鼠未能显示出对苯丙胺攻击的显着刻板行为举止。因此，结果表明，预先暴露于单一高剂量的苯丙胺会产生对苯丙胺诱导的刻板行为的情境和反应依赖性敏化。

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