• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Estrous cyclicity and behavioral sensitization in female rats following repeated intravenous cocaine administration.
【24h】

Estrous cyclicity and behavioral sensitization in female rats following repeated intravenous cocaine administration.

机译：重复静脉注射可卡因后，雌性大鼠的发情周期和行为敏化作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Repeated intermittent administration of cocaine is well known to produce behavioral sensitization in male animals. The present studies explored whether intact adult female rats maintained normal estrous patterns in response to repeated IV cocaine administration and whether behavioral sensitization occurred with this route of administration. Adult female Sprague-Dawley rats (N = 48) were surgically implanted with an intravenous access port. Animals received 3.0 mg/kg IV cocaine once/day for 14 days. Daily vaginal lavages indicated that female rats continued to cycle normally throughout the experiment. Estimates of statistical power for detecting alterations in estrous cycle length ranged from 0.61-0.95 for small (0.1) to large (0.4) effect sizes. Moreover, no cocaine-treated animals displayed persistent vaginal estrus or were acyclic and cocaine treatment did not decrease body weight. Immediately after the cocaine injection, animals were placed in IR photocell activity chambers for 60 min. Female rats displayed a significant 75% increase in locomotor activity across the 14-day time course of IV cocaine injections. These data indicate that 3.0 mg/kg of IV cocaine does not interfere with normal estrous cyclicity, and that behavioral sensitization occurs in female rats following repeated daily IV cocaine dosing. Collectively, these data suggest that the IV cocaine-dosing model may be particularly useful in exploring the gender-dependent effects of cocaine using intact female rats.
机译：众所周知，可卡因的反复间歇给药会在雄性动物中产生行为致敏作用。本研究探讨了完整的成年雌性大鼠是否响应重复的可卡因重复给药而保持正常的发情模式，以及这种给药途径是否发生了行为敏化。成年雌性Sprague-Dawley大鼠（N = 48）被手术植入了静脉通路。动物每天接受一次3.0 mg / kg的可卡因静脉注射，持续14天。每天进行阴道灌洗表明，在整个实验过程中，雌性大鼠继续正常循环。用于检测发情周期长度变化的统计功效的估计值范围从小（0.1）到大（0.4）效应范围为0.61-0.95。此外，没有可卡因治疗的动物表现出持续的阴道发情或无环，可卡因治疗并没有减轻体重。注射可卡因后，立即将动物置于红外光电池活动室中60分钟。在静脉注射可卡因的14天时间范围内，雌性大鼠的运动活动显着增加了75％。这些数据表明，静脉注射可卡因3.0 mg / kg不会干扰正常的发情周期，并且每天重复静脉注射可卡因后，雌性大鼠会出现行为敏化现象。总体而言，这些数据表明，静脉注射可卡因的剂量模型在使用完整雌性大鼠探索可卡因的性别依赖性效应中可能特别有用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号