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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Contribution of GABA(A) and GABA(B) receptors to the discriminative stimulus produced by gamma-hydroxybutyric acid.
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Contribution of GABA(A) and GABA(B) receptors to the discriminative stimulus produced by gamma-hydroxybutyric acid.

机译：GABA（A）和GABA（B）受体对由γ-羟基丁酸产生的区分性刺激的贡献。

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摘要

The present study examined the involvement of GABA(A) and GABA(B) receptors in the discriminative stimulus effects of gamma-hydroxybutyric acid (GHB). Rats were trained to discriminate either 300 or 700 mg/kg GHB IG from water using a T-maze, food-reinforced drug-discrimination procedure. The direct GABA(B) agonist, baclofen, substituted completely for both training doses of GHB; its potency to substitute for GHB increased moderately as the training dose of GHB was increased. The positive GABA(A) modulator, diazepam, substituted partially for 300 mg/kg GHB, but failed to elicit GHB-appropriate responding in rats trained with the higher GHB dose. Finally, the GABA(B) antagonist, CGP 35348, completely blocked the discriminative stimulus effects of the high training dose of GHB, but only partially antagonized the effects of the low training dose. These results suggest that (a) GHB produces a compound stimulus, and (b) both GABA(B)- and GABA(A)-mediated cues are prominent components of this compound stimulus; the contribution of each component, however, appears to vary as the training dose of GHB is increased.
机译：本研究检查了GABA（A）和GABA（B）受体在γ-羟基丁酸（GHB）的判别刺激作用中的参与。使用T迷宫，食物强化药物区分程序，训练大鼠从水中区分300或700 mg / kg GHB IG。直接的GABA（B）激动剂巴氯芬完全替代了两种训练剂量的GHB;随着GHB训练剂量的增加，其替代GHB的能力适度增加。积极的GABA（A）调节剂地西epa可部分替代300 mg / kg GHB，但在高GHB剂量训练的大鼠中未能引起GHB适当的应答。最后，GABA（B）拮抗剂CGP 35348完全阻止了高训练剂量GHB的歧视性刺激作用，但仅部分拮抗了低训练剂量的GHB。这些结果表明：（a）GHB产生复合刺激，并且（b）GABA（B）和GABA（A）介导的提示都是该复合刺激的主要组成部分;但是，随着GHB训练剂量的增加，每种成分的作用似乎也不同。

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