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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Evidence for an action of araboascorbic acid on dopaminergic pathways of the corpus striatum.
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Evidence for an action of araboascorbic acid on dopaminergic pathways of the corpus striatum.

机译：阿拉伯抗坏血酸对纹状体多巴胺能途径的作用的证据。

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摘要

The relative decrease in the 2 h accumulation of administered [3H]-spiperone (SPI)-2 muCi/kg, 0.0004 mg/kg, s.c. - in mouse corpus striatum, a brain area with a high dopaminergic input (specific plus nonspecific dopamine receptor ligand binding) and the cerebellum, a brain area with little, if any, dopaminergic input (an index of nonspecific dopamine receptor ligand binding) were used to compare the influence of araboascorbic acid (AraA) with ascorbic acid (AsA) on the dopamine receptor. The abilities of these compounds to potentiate haloperidol-induced catalepsy were also investigated. Pretreatment for 30 min with AraA (1000 or 2000 mg/kg, i.p.) produced the same dose-dependent decrease in SPI accumulation in corpus striatum as observed with AsA. Accumulation in cerebellum was unaffected by either agent. Furthermore, as previously shown for AsA in rats and monkeys, AsA (1000 mg/kg) potentiated the cataleptogenic effect of haloperidol (0.2 mg/kg, s.c.). AraA was at least as effective as AsA in potentiating catalepsy produced by the neuroleptic. Thus, it would appear that AraA influenced the dopamine receptor in a manner not unlike that already shown for AsA. Because both agents have almost identical redox potentials but divergent antiscorbutic activities, their reductive properties might be more pertinent to the observed effects than their antiscorbutic properties.
机译：施用的[3H]-哌啶（SPI）-2 muCi / kg，0.0004 mg / kg，皮下注射的2小时累积相对减少。 -在小鼠纹状体中，使用多巴胺能输入较高的大脑区域（特异性加上非特异性多巴胺受体配体结合）和小脑，使用多巴胺能输入很少（如果有的话）的大脑区域（非特异性多巴胺受体配体结合指数）比较阿拉伯糖抗坏血酸（AraA）和抗坏血酸（AsA）对多巴胺受体的影响。还研究了这些化合物增强氟哌啶醇诱导的僵直的能力。用AraA（1000或2000 mg / kg，i.p.）预处理30分钟后，纹状体中SPI积累的剂量依赖性下降与AsA观察到的相同。小脑的蓄积不受任何一种药物的影响。此外，如先前在大鼠和猴子中对AsA所显示的那样，AsA（1000 mg / kg）增强了氟哌啶醇（0.2 mg / kg，s.c.）的致晕作用。在增强抗精神病药产生的僵直症方面，AraA至少与AsA一样有效。因此，看来AraA以与AsA已经显示的不同的方式影响多巴胺受体。因为这两种药物具有几乎相同的氧化还原电位，但抗坏血酸活性不同，所以它们的还原性可能比其抗坏血酸性质与所观察到的效果更相关。

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