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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Drug discrimination training with low doses: maintenance of discriminative control.
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Drug discrimination training with low doses: maintenance of discriminative control.

机译：低剂量的药物歧视培训：保持歧视性控制。

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摘要

Procedures are reported that maintain control by the drug cue during and after drug discrimination training with lower doses that yield predominantly vehicle-appropriate choices. Twelve pigeons were trained to discriminate chlordiazepoxide (CDP) from saline using two-key (drug vs. vehicle) drug discrimination procedures. Intermixed within each block of 30 sessions were nine sessions of training with 8.0 mg/kg CDP, nine with one of seven lower training doses (4.0, 2.8, 2.0, 1.4, 1.0, 0.7, or 0.5 mg/kg CDP), and 12 with saline. The lower training dose was decreased across blocks. The three lowest training doses (1.0, 0.7, and 0.5 mg/kg CDP) yielded predominantly saline-appropriate choices but had no effect on discrimination of 8.0 mg/kg CDP or saline. Three doses (2.0, 1.4, and 1.0 mg/kg CDP) were retrained, and each yielded percentages of drug-appropriate choices nearly identical to those obtained during previous training. This drug discrimination procedure maintains control by the drug cue during and after training with vehicle-like doses of the training drug and may allow for repeated assessment of effects of low training doses.
机译：据报道，程序在药物歧视训练期间和之后通过药物提示保持控制，并以较低的剂量产生主要为媒介物的适当选择。训练了十二只鸽子，使用两键（药物对媒介物）药物区分程序从盐水中区分出氯二氮卓（CDP）。在每30个阶段的训练中，混合了9个训练阶段的8.0 mg / kg CDP，9个训练阶段的7种较低的训练剂量（4.0、2.8、2.0、1.4、1.0、0.7或0.5 mg / kg CDP）之一和12用盐水。跨块降低了较低的训练剂量。三种最低的培训剂量（1.0、0.7和0.5 mg / kg CDP）主要产生了适合盐水的选择，但对8.0 mg / kg CDP或盐水的区分没有影响。重新训练了三剂（2.0、1.4和1.0 mg / kg CDP），每种剂量产生的药物合适选择百分率几乎与先前训练中获得的相同。该药物区分程序在使用媒介物剂量的训练药物进行训练期间和之后，通过药物提示来保持控制，并且可以允许重复评估低训练剂量的效果。

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