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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Triazolam in Alzheimer's disease: pilot study on sleep and memory effects.
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Triazolam in Alzheimer's disease: pilot study on sleep and memory effects.

机译：三唑仑在阿尔茨海默氏病中：关于睡眠和记忆效应的初步研究。

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We examined the effects on sleep and memory of a nighttime dose of triazolam, 0.125 mg, in seven subjects with Alzheimer's disease (AD) who were reported by caregivers to be frequently up at night. Subjects were admitted to an intermediate care hospital ward for the 8-day ABA design protocol (placebo baseline-drug-placebo washout). Drug or placebo was given each evening at 2100 h. Sleep was assessed with a wrist-worn activity monitor. Memory was evaluated using a computerized delayed-matching-to-sample (DMTS) task administered at 0800 and 2130 h. Triazolam had no significant effects on total sleep time at night, latency to sleep onset, number of arousals, or time asleep during the day. DMTS performance was significantly worse at night compared to morning during baseline, but there were no significant drug effects. Our results suggest the standard geriatric dose of triazolam, 0.125 mg, may not be an effective hypnotic in AD patients with disrupted sleep, but neither does it substantially worsen the recent memory deficits of AD.
机译：我们在护理人员报告的七名患有阿尔茨海默氏病（AD）的受试者中检查了夜间剂量三唑仑0.125 mg对睡眠和记忆的影响，据护理人员报告，这些受试者经常在晚上起床。受试者入院接受8天ABA设计方案（安慰剂基线-药物-安慰剂冲洗）的中级护理医院病房。每天晚上2100小时服用药物或安慰剂。用腕戴式活动监测仪评估睡眠。使用在0800和2130小时进行的计算机化的样本延迟匹配（DMTS）任务评估内存。三唑仑对夜间总睡眠时间，入睡潜伏期，唤醒次数或白天入睡时间没有显着影响。与基线期间的早晨相比，晚上的DMTS性能明显较差，但没有明显的药物作用。我们的研究结果表明，三唑仑的标准老年剂量0.125 mg，对于睡眠中断的AD患者可能不是有效的催眠药，但也不会显着恶化近期的AD记忆障碍。

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