• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Effects of ibogaine on sensory-motor function, activity, and spatial learning in rats.
【24h】

Effects of ibogaine on sensory-motor function, activity, and spatial learning in rats.

机译：依博加因对大鼠感觉运动功能，活动和空间学习的影响。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Ibogaine, a naturally occurring alkaloid, has been show to reduce naloxone-precipitated withdrawal symptoms from morphine. Given the clinical possibilities, it is important to determine ibogaine's effects on sensory-motor function, activity, learning, and memory. Long-Evans rats injected with doses of 20-60 mg/kg of ibogaine displayed slower response times on sensory and sensory-motor tests and were impaired in performing specific motor reflexes at doses of 40-60 mg/kg. Furthermore, these rats showed a marked reduction in locomotor and nonlocomotor activity, as well as emotionality at doses ranging from 10-40 mg/kg. At the higher doses the rats appeared to be virtually inactive. There were also deficits in learning a spatial location task (a dry-land version of the Morris water-maze). The deficits, however, were probably due to a reduction in locomotor activity and reduction in detection of sensory information. In a final experiment, a single injection of 40 mg/kg of ibogaine had marked deleterious effects on the acquisition of the spatial location task 1 but not 7 days after the injection, even though in this case there were no effects on sensory motor function 1 or 7 days after the injection. Thus, there are severe sensory-motor activity and learning problems while the animal is under the influence of ibogaine (acute effect) as well as long-term consequences on learning without concomitant changes in sensory-motor function.
机译：已证明，天然存在的生物碱伊博加因可减轻纳洛酮从吗啡引起的戒断症状。考虑到临床可能性，确定依博加因对感觉运动功能，活动，学习和记忆的影响很重要。注射20-60 mg / kg依博加因的Long-Evans大鼠在感觉和感觉运动试验中显示出较慢的响应时间，并且在以40-60 mg / kg的剂量进行特定的运动反射时受到损害。此外，这些大鼠在10-40 mg / kg的剂量范围内显示出自发运动和非自发运动以及情绪低落。在较高剂量下，大鼠似乎实际上是不活动的。在学习空间定位任务（莫里斯水迷宫的旱地版本）方面也存在缺陷。然而，该缺陷可能是由于运动活动的减少和感觉信息的检测的减少。在最终实验中，单次注射40 mg / kg的依博加因对完成空间定位任务1产生了明显的有害影响，但注射后7天却没有，尽管在这种情况下对感觉运动功能没有影响1或注射后7天。因此，当动物在依博加因的影响下（急性作用）存在严重的感觉运动活动和学习问题，以及对学习的长期后果，而感觉运动功能没有随之变化。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号