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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Median raphe injections of 8-OH-DPAT lower frequency thresholds for lateral hypothalamic self-stimulation.
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Median raphe injections of 8-OH-DPAT lower frequency thresholds for lateral hypothalamic self-stimulation.

机译：中位数8-OH-DPAT较低阈值下侧丘脑自我刺激的缝线注入。

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摘要

The selective 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) reduces the activity of brain 5-HT neurons via somatodendritic autoreceptors located in the midbrain raphe nuclei. This action of 8-OH-DPAT results in reduced 5-HT synthesis and release of 5-HT in terminal regions. Previous studies have shown that injecting 8-OH-DPAT into the raphe nuclei stimulates feeding, sexual behaviour, and locomotor activity, and serves as an unconditioned stimulus for inducing a conditioned place preference. This behavioural profile suggests that raphe injections of 8-OH-DPAT facilitate reward-related behaviour. The present study tested this hypothesis by investigating the effects of median raphe injections of 8-OH-DPAT on sensitivity to lateral hypothalamic (LH) self-stimulation. Frequencies required to sustain half-maximal rates of responding were determined following injection of saline or various doses of 8-OH-DPAT (0.2-5 micrograms) into the median raphe. In four rats with accurate injection sites 8-OH-DPAT dose-dependently lowered frequency thresholds by up to 40%. In the remaining rats injection sites were located outside the median raphe, and 8-OH-DPAT either slightly raised or failed to lower frequency thresholds. These results show that 8-OH-DPAT injected into the median raphe facilitates brain stimulation reward, and suggest that acute reductions in 5-HT neurotransmission may enhance sensitivity to rewarding stimuli. The possible interactions between 5-HT neurons and efferent systems utilizing dopamine and acetylcholine as neurotransmitters in mediating this effect are discussed.
机译：选择性5-HT1A激动剂8-羟基-2-（二-正丙基氨基）四氢化萘（8-OH-DPAT）通过位于中脑中枢核内的树突状自体受体降低脑5-HT神经元的活性。 8-OH-DPAT的这种作用导致5-HT合成减少和5-HT在末端区域释放。先前的研究表明，将8-OH-DPAT注射到缝核中，可刺激进食，性行为和运动活动，并作为诱导条件性偏爱的无条件刺激。这种行为特征表明，对8 OH-DPAT进行点阵注针有助于促进与奖赏相关的行为。本研究通过调查中位数raph注射8-OH-DPAT对外侧下丘脑（LH）自刺激敏感性的影响，验证了该假设。将盐水或各种剂量的8-OH-DPAT（0.2-5微克）注入中位数网眼后，确定维持半数最大响应速率所需的频率。在具有精确注射部位的四只大鼠中，8-OH-DPAT剂量依赖性地将频率阈值降低了40％。在其余的大鼠中，注射位点位于中位数网格之外，并且8-OH-DPAT略微升高或未能降低频率阈值。这些结果表明，向正中缝注入8-OH-DPAT可以促进脑刺激奖励，并表明5-HT神经传递的急性减少可能会增强对奖励刺激的敏感性。讨论了5-HT神经元与利用多巴胺和乙酰胆碱作为神经递质的传出系统之间在介导这种作用中可能的相互作用。

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