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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >NS-3, a TRH-analog, reverses memory disruption by stimulating cholinergic and noradrenergic systems.
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NS-3, a TRH-analog, reverses memory disruption by stimulating cholinergic and noradrenergic systems.

机译：NS-3是TRH的类似物，可通过刺激胆碱能和去甲肾上腺素能系统来逆转记忆力破坏。

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The effects of a TRH-analog, N[[(3R,6R)-6-methyl-5-oxo-3-thiomorpholinyl]carbonyl]-L-histidyl-L - prolinamide tetrahydrate (NS-3, CG3703, montirelin hydrate) were compared with those of physostigmine on learning and memory disruption in the passive avoidance response (PAR) induced by either electrolytic lesion of the nucleus basalis magnocellularis (NBM) or by treatment with the noradrenergic neurotoxin, N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4) in rats. a) In NBM-lesioned rats, both NS-3 and physostigmine significantly reversed disruption of memory consolidation examined 15 min after the training session when these drugs were injected IP immediately after the training session. In addition, reversal by NS-3 (0.1 mg/kg) of the disruption of memory was observed even in the retention test conducted 24 h after the training session. b) NS-3 (0.5 mg/kg) significantly reversed the disruption of memory retrieval, when the drug was administered 15 min before the test session. c) DSP4 (50 mg/kg IP) caused memory disruption when the retention tests were conducted between 1 and 48 h after the acquisition session. NS-3 (0.1 mg/kg), but not physostigmine, significantly reversed the disruption of memory induced by DSP4 treatment. These findings suggest that the consistent antiamnestic action of NS-3 is due to the enhancement of both central cholinergic and noradrenergic systems, possibly via facilitation of the release of these transmitters.
机译：TRH类似物N [[（3R，6R）-6-甲基-5-氧代-3-硫代吗啉基]羰基] -L-组氨酸-L-脯氨酰胺四水合物（NS-3，CG3703，montirelin水合物）的作用将其与毒扁豆碱的药物相比，比较了基底回生核的电解损伤或通过去甲肾上腺素能神经毒素N-（2-氯乙基）-N-引起的被动回避反应（PAR）中的学习和记忆破坏大鼠乙基-2-溴苄胺（DSP4）。 a）在NBM损伤的大鼠中，NS-3和毒扁豆碱均能显着逆转训练后15分钟检查的记忆巩固破坏，而在训练后立即腹膜内注射这些药物。另外，即使在训练后24小时进行的保留试验中，也观察到NS-3（0.1mg / kg）的记忆破坏逆转。 b）NS-3（0.5 mg / kg）在测试前15分钟给药时，显着逆转了记忆恢复的中断。 c）当在采集阶段后1至48小时内进行保留测试时，DSP4（50 mg / kg IP）导致记忆破坏。 NS-3（0.1 mg / kg）而非毒扁豆碱可显着逆转DSP4处理诱导的记忆破坏。这些发现表明，NS-3的持续抗记忆作用是由于中央胆碱能和去甲肾上腺素能系统的增强，可能是通过促进这些递质的释放。

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