• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacology, Biochemistry and Behavior >The influence of open arm ledges and maze experience in the elevated plus-maze.
【24h】

The influence of open arm ledges and maze experience in the elevated plus-maze.

机译：在高架迷宫中，张开的臂架和迷宫的影响。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In Experiment 1, rats were tested in a plus-maze, with or without small ledges on the open arms, after injection with vehicle or chlordiazepoxide (7.5 mg/kg). They were scored either on their first or second exposure to the maze; those scored on trail 2 had received a 5-min undrugged exposure to the maze 24 h earlier. This dose of chlordiazepoxide had a significant anxiolytic effect on trial 1 only in the maze without ledges, and on trial 2 only in the maze with ledges; thus, the presence of ledges differentially affected anxiolytic sensitivity on trials 1 and 2. The results of a factor analysis study (Experiment 2) confirmed that ledges had a differential effect when rats were repeatedly exposed to the maze. Thus, in the maze without ledges, the scores reflecting anxiolytic activity on trial 1 loaded on one factor, whereas the scores from trials 2 and 3 loaded on another independent factor. In the maze with ledges, the scores reflecting anxiolytic activity on trials 1, 2, and 3 loaded on three independent factors. Considering the published evidence and the results of the present study, we suggest that both types of plus-maze may be measuring the same type of anxiety with different sensitivities on trial 1 (e.g., generalised anxiety or fear of open spaces); different types of anxiety on trial 2 (without ledges--phobia/fear of heights; with ledges--not known), and trial 3 in the maze with ledges, yet another type of anxiety. The factor analysis results are also presented for ethological measures on the plus-maze, and for activity and exploration in the holeboard. Based on the factor loadings, a composite measure of anxiety on trial 1 is presented which will increase the sensitivity of the plus-maze to anxiolytic treatments. The measures of motor activity in the plus-maze load on a different factor from those derived from the holeboard, thus cautioning against considering all measures of motor activity as interchangeable.
机译：在实验1中，在注射了媒介物或氯二氮卓（7.5 mg / kg）后，在正迷宫中对大鼠进行了测试，无论其开口臂上有无小凸缘。他们是在第一次或第二次接触迷宫时被打分的;那些在第2条路径上得分的人在24小时前接受了5分钟的非暴露于迷宫的暴露。仅在没有壁架的迷宫中，该剂量的氯二氮杂on对试验1具有显着的抗焦虑作用;仅在有壁架的迷宫中，该剂量的对试验2具有显着的抗焦虑作用。因此，壁架的存在对试验1和2的抗焦虑敏感性有不同的影响。一项因子分析研究（实验2）的结果证实，当大鼠反复暴露于迷宫中时，壁架具有不同的作用。因此，在没有壁架的迷宫中，反映试验1的抗焦虑活性的得分是一个因素，而试验2和3的得分是另一个独立因素。在带有壁架的迷宫中，反映试验1、2和3的抗焦虑活性的得分取决于三个独立因素。考虑到已发表的证据和本研究的结果，我们建议两种类型的正迷宫都可能在试验1上以不同的敏感性测量相同类型的焦虑（例如，普遍性焦虑或对开放空间的恐惧）;试验2的不同类型的焦虑（无壁架-恐惧症/对身高的恐惧;没有壁架-未知），以及迷宫中的试验3有壁架的焦虑，这是另一种类型的焦虑。还提供了因素分析结果，用于在迷宫中进行行为学测量，并在洞洞板上进行活动和探索。基于因素负荷，提出了一项关于试验1的综合焦虑量度，它将增加正迷宫对抗焦虑治疗的敏感性。在迷宫载荷中的运动活动性度量与从孔板得出的运动因子不同，因此要注意不要将所有运动活动性度量视为可互换。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号