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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Cannabinoid and dopamine interaction in rodent brain: effects on locomotor activity.
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Cannabinoid and dopamine interaction in rodent brain: effects on locomotor activity.

机译：啮齿动物大脑中的大麻素和多巴胺相互作用：对运动活性的影响。

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We investigated interactions between cannabinoid and dopamine receptor systems in ICR mice. Mice were treated with the cannabinoid agonist levonantradol, the D(1) dopamine agonist 6-Br-APB, or the D(2) dopamine agonist quinelorane, or with combinations of these drugs. In addition, the D(1) antagonist SCH23390 was administered both alone and in combination with levonantradol. Two tests were used to evaluate changes in motor function: the immobility (ring stand) test and the catalepsy (bar) test. Levonantradol increased immobility and catalepsy in a dose-dependant manner. Both the D(2) agonist quinelorane and the D(1) agonist 6-Br-APB were able to attenuate the motor dysfunction caused by levonantradol. Administration of the D(1) antagonist SCH23390 enhanced the effects of levonantradol, producing a leftward shift of the log dose-response curve. These results differ from the augmentation by D(2) agonists of the hypoactivity induced by levonantradol in non-human primates [Meschler JP, Clarkson FA, Mathew PJ, Howlett AC, Madras BK. D(2), but not D(1) dopamine receptor agonists potentiate cannabinoid-induced sedation in nonhuman primates. J Pharmacol Exp Ther 2000;292:952-959], suggesting that conclusions about the interactions between the dopamine and cannabinoid receptor motor systems in rodents may not extend to primates.
机译：我们研究了ICR小鼠中大麻素和多巴胺受体系统之间的相互作用。小鼠用大麻素激动剂左炔诺醇，D（1）多巴胺激动剂6-Br-APB或D（2）多巴胺激动剂喹诺罗烷或这些药物的组合治疗。此外，D（1）拮抗剂SCH23390既可以单独使用，也可以与左苯二酚组合使用。两项测试用于评估运动功能的变化：固定性（环站）测试和僵直性（杠铃）测试。左苯二酚以剂量依赖性方式增加不动和僵直。 D（2）激动剂奎诺环烷和D（1）激动剂6-Br-APB都能够减轻由左苯二酚引起的运动功能障碍。 D（1）拮抗剂SCH23390的给药增强了左苯二酚的作用，使log剂量-响应曲线向左移动。这些结果不同于D（2）激动剂对非人灵长类动物中由左苯二酚引起的机能减退[Meschler JP，Clarkson FA，Mathew PJ，Howlett AC，Madras BK。 D（2），但不是D（1）多巴胺受体激动剂可增强大麻素诱导的非人灵长类动物的镇静作用。 J Pharmacol Exp Ther 2000; 292：952-959]，表明关于啮齿动物中多巴胺和大麻素受体运动系统之间相互作用的结论可能不会延伸到灵长类动物。

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