• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Neurobiological responses to ethanol in mutant mice lacking neuropeptide Y or the Y5 receptor.
【24h】

Neurobiological responses to ethanol in mutant mice lacking neuropeptide Y or the Y5 receptor.

机译：缺少神经肽Y或Y5受体的突变小鼠对乙醇的神经生物学反应。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We have previously shown that voluntary ethanol consumption and resistance are inversely related to neuropeptide Y (NPY) levels in NPY-knockout (NPY -/-) and NPY-overexpressing mice. Here we report that NPY -/- mice on a mixed C57BL/6Jx129/SvEv background showed increased sensitivity to locomotor activation caused by intraperitoneal (ip) injection of 1.5 g/kg of ethanol, and were resistant to sedation caused by a 3.5-g/kg dose of ethanol. In contrast, NPY -/- mice on an inbred 129/SvEv background consumed the same amount of ethanol as wild-type (WT) controls at 3%, 6%, and 10% ethanol, but consumed significantly more of a 20% solution. They exhibited normal locomotor activation following a 1.5-g/kg injection of ethanol, and displayed normal sedation in response to 2.5 and 3.0 g/kg of ethanol, suggesting a genetic background effect. Y5 receptor knockout (Y5 -/-) mice on an inbred 129/SvEv background showed normal ethanol-induced locomotor activity and normal voluntary ethanol consumption, but displayed increased sleep time caused by 2.5 and 3.0 g/kg injection of ethanol. These data extend previous results by showing that NPY -/- mice of a mixed C57BL/6Jx129/SvEv background have increased sensitivity to the locomotor activation effect caused by a low dose of ethanol, and that expression of ethanol-related phenotypes are dependent on the genetic background of NPY -/- mice.
机译：先前我们已经表明，在NPY基因敲除（NPY-/-）和NPY过表达的小鼠中，自愿的乙醇消耗和抗性与神经肽Y（NPY）水平成反比。在这里，我们报告说，在混合C57BL / 6Jx129 / SvEv背景上的NPY-/-小鼠显示出对腹膜内（ip）注射1.5 g / kg乙醇引起的运动激活的敏感性增加，并且对3.5 g引起的镇静具有抵抗力/ kg的乙醇剂量。相比之下，在近交129 / SvEv背景下的NPY-/-小鼠与野生型（WT）对照在3％，6％和10％的乙醇中消耗了相同量的乙醇，但是在20％的溶液中消耗了更多的乙醇。他们在注射1.5 g / kg乙醇后表现出正常的运动激活，并在对2.5和3.0 g / kg乙醇的反应中表现出正常的镇静作用，表明具有遗传背景作用。在近交129 / SvEv背景上的Y5受体基因敲除（Y5-/-）小鼠表现出正常的乙醇诱导的运动活性和正常的自愿性乙醇消耗，但是由于2.5和3.0 g / kg的乙醇注射而导致睡眠时间增加。这些数据扩展了以前的结果，显示了混合C57BL / 6Jx129 / SvEv背景的NPY-/-小鼠对低剂量乙醇引起的自发激活作用的敏感性增加，并且乙醇相关表型的表达依赖于NPY-/-小鼠的遗传背景。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号