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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Pharmacology of sucrose-reinforced place-preference conditioning: effects of naltrexone.
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Pharmacology of sucrose-reinforced place-preference conditioning: effects of naltrexone.

机译：蔗糖增强的位置偏好条件的药理作用：纳曲酮的作用。

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Two experiments investigated the role of the opioid system in sucrose-reinforced conditioned place preferences (CPPs) in rats. Experiment 1 examined the effects of a general opioid antagonist, naltrexone, on the expression of a CPP acquired in the absence of the drug. Subjects were trained to associate one compartment of a two-compartment chamber with sucrose and the other compartment with water. Rats displayed a preference for the sucrose-associated compartment in a choice test without sugar or water available following vehicle saline treatment. Naltrexone doses of 2.5 and 5.0 mg/kg reduced this preference for the sucrose-associated compartment. Experiment 2 examined the effects of naltrexone on the acquisition as well as the expression of CPPS. Different groups of rats received daily injections of either saline, 0.1, 1.0, or 5.0 mg/kg of naltrexone prior to each training session, and then these groups were given a choice test for the CPP after saline or naltrexone injections. Although naltrexone treatment attenuated the expression of CPPs in each group relative to saline treatment, there were no group differences during these tests in the magnitude of the preferences. Moreover, all groups displayed equal acquisition of CPPs despite the fact that naltrexone dose dependently decreased sucrose intake during the training phase. Together, the results indicate that the opioid system modulates the expression but not the acquisition of sucrose-reinforced CPPs.
机译：两项实验研究了阿片样物质系统在大鼠蔗糖增强的条件性位置偏爱（CPP）中的作用。实验1检查了普通阿片类药物拮抗剂纳曲酮对在不存在药物的情况下获得的CPP表达的影响。训练对象使两室腔室的一个腔室与蔗糖相关联，另一腔室与水相关联。在选择测试中，大鼠表现出对与蔗糖相关的区室的偏爱，而在载体盐水处理后没有糖或水可用。纳曲酮剂量分别为2.5和5.0 mg / kg，降低了对蔗糖相关隔室的偏爱。实验2检查了纳曲酮对获得性和CPPS表达的影响。在每次训练之前，不同组的大鼠每天注射盐水，0.1、1.0或5.0 mg / kg纳曲酮，然后在注射盐水或纳曲酮后对这些组进行CPP选择测试。尽管纳曲酮治疗相对于生理盐水治疗降低了每组中CPP的表达，但在这些测试中，偏好程度没有组间差异。而且，尽管纳曲酮剂量在训练阶段依赖地减少了蔗糖的摄入量，但所有组的CPP摄取量均相等。在一起，结果表明，阿片样物质系统调节表达，但不调节蔗糖增强的CPP。

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