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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Effects of repeated morphine on cerebral dopamine release and metabolism in AA and ANA rats.
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Effects of repeated morphine on cerebral dopamine release and metabolism in AA and ANA rats.

机译：重复吗啡对AA和ANA大鼠脑多巴胺释放和代谢的影响。

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摘要

Cerebral dopaminergic mechanisms were studied in the nucleus accumbens and caudate-putamen of alcohol-preferring AA (Alko Alcohol) and alcohol-avoiding ANA (Alko Non-Alcohol) rats after 4-day repeated morphine treatment. This treatment has been shown to enhance the locomotor activity stimulating effect of morphine in the AA but not in the ANA rats. Morphine (1 or 3 mg/kg) or saline was administered subcutaneously once daily and the extracellular concentrations of dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) were measured, in freely moving rats by in vivo microdialysis on days 1 and 4. Morphine increased accumbal DA, DOPAC and HVA similarly in rats of both lines, and no sensitization of DA release or metabolism was seen in rats of either line given morphine repeatedly. In the caudate-putamen, morphine increased DA, DOPAC and HVA significantly only in the AA rats. During repeated treatment, the morphine-induced elevation of DA metabolites, but not that of DA, was enhanced similarly in rats of both lines. These results suggest that the effects of acute morphine administration on nigrostriatal dopaminergic mechanisms are stronger in the AA than in the ANA rats, whereas the effects of morphine on mesolimbic dopaminergic systems do not differ. Furthermore, in rats of both lines, repeated morphine treatment enhanced the responses of the nigrostriatal dopaminergic systems similarly, but no enhancement occurred in the mesolimbic systems of rats of either line. These findings do not support the critical role of accumbal dopaminergic systems in morphine-induced behavioural sensitization.
机译：经过4天反复吗啡处理后，研究了偏爱酒精的AA（Alko Alcohol）和偏爱酒精的ANA（Alko Non-Alcohol）大鼠伏隔核和尾状壳中脑的多巴胺能机制。已显示该处理在AA中增强了吗啡的运动活性刺激作用，但在ANA大鼠中却没有。每天一次皮下注射吗啡（1或3 mg / kg）或生理盐水，并通过自由移动的大鼠，测量自由运动大鼠的多巴胺（DA），3,4-二羟基苯基乙酸（DOPAC）和高香草酸（HVA）的细胞外浓度。在第1天和第4天进行体内微透析。吗啡在两个品系的大鼠中都类似地增加了DA，DOPAC和HVA的累积量，并且在重复给予吗啡的两个品系的大鼠中均未观察到DA释放或代谢的敏化。在尾状丘脑中，吗啡仅在AA大鼠中显着增加DA，DOPAC和HVA。在重复治疗期间，两种品系大鼠的吗啡诱导的DA代谢产物升高，但DA均没有升高。这些结果表明，急性吗啡给药对AA的黑质纹状体多巴胺能机制的影响强于ANA大鼠，而吗啡对中脑边缘多巴胺能系统的影响没有差异。此外，在两个系的大鼠中，重复的吗啡处理均类似地增强了黑纹状体多巴胺能系统的反应，但是在任一系的中脑边缘系统中均没有增强。这些发现不支持伏安多巴胺能系统在吗啡诱导的行为敏化中的关键作用。

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