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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Prenatal morphine exposure alters N-methyl-D-aspartate- and kainate-induced seizures in adult male rats.
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Prenatal morphine exposure alters N-methyl-D-aspartate- and kainate-induced seizures in adult male rats.

机译：产前吗啡暴露会改变成年雄性大鼠的N-甲基-D-天冬氨酸和海藻酸盐诱导的癫痫发作。

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摘要

The purpose of the present study was to investigate whether prenatal exposure to morphine has effects on excitatory amino acid-induced seizures. Adult male rats, exposed on embryonic days 11-18 to saline or morphine, were injected with N-methyl-D-aspartate (NMDA) (150, 175, 200, 225, and 250 mg/kg) or kainic acid (KA) (15 or 20 mg/kg) in adulthood to assess the occurrence and latency to onset of stereotypy and seizures. The latency to onset of stereotypy was significantly increased after 175 mg/kg, and decreased after 200 mg/kg of NMDA in morphine-exposed animals. The lowest dose of NMDA (150 mg/kg) induced seizures in prenatally saline-treated control male rats but not in the morphine-exposed male rats. In the KA-injected group, prenatally morphine-exposed males had shorter latency to onset of wet-dog shakes, but there were no effects on the latency to onset of clonic seizures. The data suggest that prenatal morphine exposure has long-term effects on seizure susceptibility and the onset of stereotypy in the excitatory amino acid-induced seizure models.
机译：本研究的目的是调查产前暴露于吗啡是否对兴奋性氨基酸诱发的癫痫发作有影响。成年雄性大鼠在胚胎第11至18天接触盐水或吗啡后，注射N-甲基-D-天门冬氨酸（NMDA）（150、175、200、225和250 mg / kg）或海藻酸（KA） （15或20 mg / kg）成年后评估刻板印象和癫痫发作的发生和潜伏期。在吗啡暴露的动物中，定型发作的潜伏期在175 mg / kg NMDA后显着增加，而在NMDA 200 mg / kg后降低。最低剂量的NMDA（150 mg / kg）在产前生理盐水处理的对照组雄性大鼠中诱发癫痫发作，但在吗啡接触的雄性大鼠中则没有诱发癫痫发作。在注射KA的组中，产前暴露于吗啡的雄性对湿狗摇动发作的潜伏期较短，但对阵挛性癫痫发作的潜伏期没有影响。数据表明，在兴奋性氨基酸诱发的癫痫发作模型中，产前吗啡暴露对癫痫发作易感性和刻板印象的发作具有长期影响。

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