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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Modulation of morphine-induced antinociception by palatable solutions in male and female rats.
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Modulation of morphine-induced antinociception by palatable solutions in male and female rats.

机译：可口溶液在雄性和雌性大鼠中对吗啡诱导的抗伤害感受的调节。

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摘要

The analgesic potency of opioid drugs varies as a function of gender, and can be modified by the intake of palatable sweet-tasting solutions. To determine if gender interacts with diet-induced changes in antinociceptive responses, male and female Long-Evans rats were fed laboratory chow and water alone, or chow, water and either a 32% w/v sucrose solution or a 0.15% w/v saccharin solution, and tested in two analgesic paradigms, the tail-flick test and the hot-plate test. For both tests, antinociceptive responses of male and female rats were tested following administration of cumulative doses (1.25, 2.5, 5.0, and 10.0 mg/kg, SC) of morphine sulfate. On the tail-flick test, morphine produced dose-related increases in antinociceptive responses. In addition, relative to both the chow only and saccharin conditions, chronic intake of the sucrose solution access significantly augmented morphine's antinociceptive properties. On the hot-plate test, when the plate was heated to 51 degrees C, morphine led to significant dose-related increases in antinociceptive responses, but diet did not affected antinociceptive responses. When the temperature of the hot plate was increased to 53 degrees C, there was a trend for animals given sucrose to have greater antinociceptive responses than those given either chow alone or saccharin. No differences in baseline pain sensitivity or morphine-induced analgesia were observed as a function of gender.
机译：阿片类药物的止痛效果随性别而变，可以通过摄入可口的甜味溶液来改变。为了确定性别是否与饮食引起的抗伤害感受性反应相互作用，雄性和雌性Long-Evans大鼠分别饲喂实验室食物和水，或食物，水和32％w / v蔗糖溶液或0.15％w / v糖精溶液，并在两种止痛范式中进行了测试：甩尾测试和热板测试。对于这两种测试，在给予累积剂量（1.25、2.5、5.0和10.0 mg / kg，SC）的硫酸吗啡后，测试了雄性和雌性大鼠的镇痛反应。在甩尾试验中，吗啡在抗伤害感受反应中产生剂量相关的增加。此外，相对于仅含糖和糖精的条件，长期摄入蔗糖溶液可显着提高吗啡的抗伤害感受性。在热板测试中，当将板加热到51摄氏度时，吗啡导致抗伤害感受性反应的剂量相关显着增加，但饮食并未影响抗伤害感受性的反应。当加热板的温度升至53摄氏度时，与单独给予食物或糖精的动物相比，给予蔗糖的动物有更大的镇痛反应。没有观察到基线疼痛敏感性或吗啡诱导的镇痛随性别的变化。

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