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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Supraadditive effect of d-fenfluramine plus phentermine on extracellular acetylcholine in the nucleus accumbens: possible mechanism for inhibition of excessive feeding and drug abuse.
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Supraadditive effect of d-fenfluramine plus phentermine on extracellular acetylcholine in the nucleus accumbens: possible mechanism for inhibition of excessive feeding and drug abuse.

机译：d-芬氟拉明加芬特明对伏隔核中细胞外乙酰胆碱的超加性作用：抑制过量摄食和药物滥用的可能机制。

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摘要

The combination of d-fenfluramine plus phentermine (d-FEN/PHEN) provides a tool for exploring neural mechanisms that control food intake and drug abuse. Prior research suggests that dopamine (DA) in the nucleus accumbens can reinforce appetitive behavior and acetylcholine (ACh) inhibits it. When rats were given d-fenfluramine (5 mg/kg, IP) DA increased to 169% (p < 0.01), and ACh decreased slightly. Phentermine (5 mg/kg, IP) increased extracellular DA to 469% of baseline and ACh increased slightly to 124% (both p < 0.01). The d-FEN/PHEN combination, however, increased both DA and ACh with a supraadditive effect on ACh to 172%. One interpretation is that dFEN/PHEN increases DA like a meal or drug of abuse, while also increasing ACh to stop further approach behavior. This leaves the animal "satiated," as defined by reduced intake of food or drugs.
机译：d-芬氟拉明与芬特明（d-FEN / PHEN）的组合为探索控制食物摄入和药物滥用的神经机制提供了一种工具。先前的研究表明伏隔核中的多巴胺（DA）可以增强食欲，而乙酰胆碱（ACh）可以抑制食欲。当大鼠给予d-氟氟拉明（5 mg / kg，IP）时，DA增至169％（p <0.01），ACh略有下降。苯丁胺（5 mg / kg，IP）使细胞外DA升高至基线的469％，ACh升高至124％（均p <0.01）。然而，d-FEN / PHEN组合可增加DA和ACh的含量，对ACh的超累加效果达到172％。一种解释是，dFEN / PHEN像进餐或滥用药物一样会增加DA，同时也会增加ACh来阻止进近行为。这使动物“吃饱了”，这是通过减少食物或药物的摄入来定义的。

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