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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Acoustic startle and fear-potentiated startle in alcohol-preferring (P) and -nonpreferring (NP) lines of rats.
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Acoustic startle and fear-potentiated startle in alcohol-preferring (P) and -nonpreferring (NP) lines of rats.

机译：酒精偏爱（P）和非酒精偏爱（NP）品系的听觉惊吓和恐惧惊吓惊吓。

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The objective of the present study was to determine whether alcohol-preferring P and -nonpreferring NP rats differ in their acoustic startle response and in fear-potentiated startle. In Experiment 1, male P and NP rats were tested on the startle response to acoustic stimuli ranging from 90-115 dB. Experiments 2 and 3 examined fear-potentiated startle and extinction of the response. In Experiment 2, rats received two light foot shock training sessions separated by 3-4 h. Testing consisted of ten acoustic startle (115 dB) and fear-potentiated startle (light preceding the acoustic startle) presentations administered every 24 h for 9 consecutive days. To test potentiated startle learning under reduced training conditions, a single training session was administered in Experiment 3, and a single within-session extinction test of 50 startle and 50 potentiated startle trials occurred the following day. Results of Experiment 1 indicated that P and NP rats did not differ in startle at any of the acoustic intensities tested. Following fear-potentiated startle conditioning in Experiment 2, however, both acoustic startle and potentiated startle responding were consistently greater in P than NP rats over most of the first 6 test days with P rats having approximately a 100% greater acoustic startle and 50-100% greater potentiated startle response. Moreover, following a single training session in Experiment 3, only P rats showed significant fear-conditioned startle. Additionally, P rats exhibited a 50-100% elevated acoustic startle response over that observed in NP rats. Taken together, the data indicate that, although experimentally naive male P and NP rats show similar acoustic startle responses, P rats become more responsive to both startle-alone and potentiated startle stimuli following fear conditioning. The change in general startle reactivity of the P rat following aversive conditioning, along with facilitated light foot shock learning, suggests that stress exposure may be an important variable in examining associations between anxiety and alcohol drinking behavior.
机译：本研究的目的是确定偏爱酒精的P和不偏爱NP的大鼠在听觉惊吓反应和恐惧增强惊吓中是否不同。在实验1中，测试了雄性P和NP大鼠对90-115 dB范围的声刺激的惊吓反应。实验2和3检查了恐惧增强的惊吓和反应的消退。在实验2中，大鼠接受了两次轻脚电击训练，每次间隔3-4小时。测试包括每24小时连续9天进行的十次听觉惊吓（115 dB）和恐惧增强惊吓（听觉惊吓之前的光）演示。为了在减少的训练条件下测试增强的惊吓学习，在实验3中进行了一次训练，第二天进行了一次50次惊吓和50次增强惊吓试验的场内绝灭测试。实验1的结果表明，在任何测试的声强下，P和NP大鼠的惊吓都没有差异。然而，在实验2中，恐惧增强了惊吓条件后，在前6个测试日的大部分时间里，P的听觉惊吓和增强的惊吓反应始终比NP大鼠要强，其中P大鼠的听觉惊吓程度增加了100％，50-100 ％增强的惊吓反应。此外，在实验3中进行一次训练后，只有P只大鼠表现出明显的恐惧条件惊吓。另外，与在NP大鼠中观察到的相比，P大鼠表现出提高的声音惊吓反应50-100％。两者合计，数据表明，尽管实验上幼稚的雄性P和NP大鼠表现出相似的听觉惊吓反应，但在恐惧调节后，P大鼠对单独的惊吓刺激和增强的惊吓刺激都变得更加敏感。厌恶性调节后，P大鼠的整体惊吓反应性的变化，以及便利的轻型足部休克学习，表明应激暴露可能是检查焦虑与饮酒行为之间关联的重要变量。

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