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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Modulation of the effects of cocaine by 5-HT1B receptors: a comparison of knockouts and antagonists.
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Modulation of the effects of cocaine by 5-HT1B receptors: a comparison of knockouts and antagonists.

机译：5-HT1B受体对可卡因作用的调节：敲除和拮抗剂的比较。

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摘要

Serotonergic transmission has been suggested to modulate the effects of cocaine. However, the specific receptors underlying this phenomenon have not been identified. To evaluate the role of the 5-HT1B receptor in mediating the actions of cocaine, we used two model systems: knockout (KO) mice lacking the 5-HT1B receptor and an acute treatment with the 5-HT1B/1D antagonist GR127935. GR127935 attenuated the ability of cocaine to stimulate locomotion and induce c-fos expression in the striatum. However, GR127935 had no apparent effect on the rewarding or sensitizing effects of cocaine. In contrast, as demonstrated previously, the 5-HT1B receptor KO mice showed a heightened locomotor response to cocaine, as well as an increased propensity to self-administer cocaine. Thus, an acute pharmacological blockade of the 5-HT1B receptor decreases some effects of cocaine, while a constitutive genetic KO of the same receptor has opposite effects. These results suggest that compensatory changes have taken place during the development of the 5-HT1B KO mice, which may have rendered these mice more vulnerable to cocaine. The 5-HT1B KO mice should therefore be considered as a genetic model of vulnerability to drug abuse rather than a classic pharmacological tool.
机译：血清素能传递已被建议调节可卡因的作用。但是，尚未发现这种现象的具体受体。为了评估5-HT1B受体在可卡因作用中的作用，我们使用了两种模型系统：缺乏5-HT1B受体的敲除（KO）小鼠和5-HT1B / 1D拮抗剂GR127935的急性治疗。 GR127935减弱了可卡因刺激纹状体运动并诱导c-fos表达的能力。但是，GR127935对可卡因的奖励或致敏作用没有明显作用。相比之下，如前所述，5-HT1B受体KO小鼠对可卡因的运动反应增强，对自我给药可卡因的倾向也增加。因此，对5-HT1B受体的急性药理阻断作用降低了可卡因的某些作用，而同一受体的组成型遗传KO具有相反的作用。这些结果表明，在5-HT1B KO小鼠的发育过程中发生了代偿性变化，这可能使这些小鼠更容易受到可卡因的侵害。因此，应将5-HT1B KO小鼠视为易受药物滥用影响的遗传模型，而不是经典的药理学工具。

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