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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Diazepam has no beneficial effects on stress-induced behavioural and endocrine changes in male tree shrews.
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Diazepam has no beneficial effects on stress-induced behavioural and endocrine changes in male tree shrews.

机译：地西p对雄性树sh的应激诱导的行为和内分泌变化无有益影响。

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摘要

The present study evaluated the effect of subchronic oral treatment of psychosocially stressed male tree shrews with diazepam on locomotor activity, marking behavior, avoidance behavior, and urinary cortisol and noradrenaline. To mimic a realistic situation of anxiolytic intervention, the treatment started 14 days after the beginning of psychosocial stress; at that time, the stress-induced behavioral and endocrine alterations had been established. The drug (5 mg/kg/day) was administered orally in the morning, while the psychosocial stress continued during the whole treatment period; the therapeutic action of diazepam treatment was followed across 7 days. Twenty-four hours after the last application serum concentrations of diazepam and its major metabolites were determined via HPLC. The results revealed concentrations of 7 ng/ml for diazepam, 106 ng/ml for nordiazepam, 22 ng/ml for temazepam, and 30 ng/ml for oxazepam. Treatment of subordinate animals with diazepam did not reveal a beneficial effect to any of the parameters studied. This contrasts to earlier findings showing that the behavioral and neuroendocrine alterations produced by this stress paradigm are sensitive to chronic treatment with the tricyclic antidepressant clomipramine. The present results support the view that in male tree shrews the state induced by psychosocial stress might be more depression related than anxiety related.
机译：本研究评估了亚地西m对受社会心理压力的雄性树sh进行亚慢性口服治疗对运动能力，标记行为，回避行为以及尿皮质醇和去甲肾上腺素的影响。为了模拟现实的抗焦虑干预情况，治疗开始于社会心理压力开始后的14天。那时，已经建立了压力引起的行为和内分泌改变。早晨口服该药（5 mg / kg /天），而在整个治疗期间持续出现社会心理压力。在7天内追踪了地西treatment的治疗作用。上次施用后二十四小时，通过HPLC测定地西epa及其主要代谢产物的血清浓度。结果显示地西epa的浓度为7 ng / ml，去甲西p的浓度为106 ng / ml，替马西m的浓度为22 ng / ml，奥沙西m的浓度为30 ng / ml。用地西epa治疗下属动物没有显示出对任何所研究参数的有益作用。这与早期发现相反，早期发现表明，这种应激范式所产生的行为和神经内分泌改变对三环抗抑郁药氯米帕明的慢性治疗敏感。目前的研究结果支持这样一种观点，即雄性树sh在心理压力下诱发的状态可能与抑郁有关，而不是与焦虑有关。

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