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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Differential effects of beta-carbolines and antidepressants on rat exploratory activity in the elevated zero-maze.
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Differential effects of beta-carbolines and antidepressants on rat exploratory activity in the elevated zero-maze.

机译：在升高的零迷宫中，β-咔啉和抗抑郁药对大鼠探索活性的不同作用。

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摘要

Present experiments were designed to compare the effects of antidepressants desipramine (10 and 20 mg/kg IP) and fluoxetine (5 and 10 mg/kg IP) with anxiogenic beta-carboline DMCM (0.5 and 1.0 mg/kg IP) in the elevated zero-maze test in rats. The second aim of this study was to assess the effects of pinoline (6-methoxy-1,2,3, 4-tetrahydro-beta-carboline) in the rat elevated zero-maze test in comparison with structurally unrelated beta-carboline DMCM and antidepressants. The time spent in the open part of the elevated zero-maze was not significantly affected by antidepressants, but was decreased by beta-carbolines pinoline and DMCM. The number of line crossings in the open parts and the number of head dips were also decreased more by beta-carbolines in comparison with antidepressants. Latency to enter the open part was statistically significantly increased only by DMCM. Measurement of locomotor activity in a separate experiment indicated that activity of the rats' time moving, distance traveled, and number of rearings were reduced by all four drugs studied. These results demonstrate that the effects of antidepressants in the elevated zero-maze test differ from the effects of the reference anxiogenic compound DMCM. The effects of pinoline and DMCM in the zero-maze test were similar, which suggests the involvement of mechanisms other than serotoninergic in the action of pinoline.
机译：本实验旨在比较抗抑郁药地昔帕明（IP和IP分别为10和20 mg / kg）和氟西汀（IP和IP为5和10 mg / kg）与血管生成的β-咔啉DMCM（IP和0.5和1.0 mg / kg）的作用大鼠迷宫测试。这项研究的第二个目的是，与结构无关的β-咔啉DMCM和DMCM相比，评估吡beta啉（6-甲氧基-1,2,3，4-四氢-β-咔啉）在大鼠零迷宫试验中的作用。抗抑郁药。抗抑郁药对在零迷宫升高的开放时间所花费的时间没有显着影响，但β-咔啉油烟碱和DMCM减少了时间。与抗抑郁药相比，β-咔啉还减少了开放部分的线交叉次数和头浸次数。据统计，仅通过DMCM，进入开放部分的延迟才显着增加。在一个单独的实验中测量运动能力表明，所研究的所有四种药物均降低了大鼠的运动时间，行进距离和饲养次数。这些结果表明，抗抑郁药在升高的零迷宫测试中的作用与参考抗焦虑药DMCM的作用不同。在零迷宫测试中，匹诺林和DMCM的作用相似，这表明除5-羟色胺能以外的其他机制也参与了匹诺林的作用。

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