• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Quantification of S-adenosylmethionine-induced tremors: a possible tremor model for Parkinson's disease.
【24h】

Quantification of S-adenosylmethionine-induced tremors: a possible tremor model for Parkinson's disease.

机译：S-腺苷甲硫氨酸引起的震颤的量化：帕金森氏病的可能的震颤模型。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Tremor is the most visible symptom of Parkinson's Disease (PD), and should be the appropriate parameter in models for its evaluation. Lack of reliable PD tremor models and methods to distinguish tremors from nontremor movements means that nontremor behavior such as rotation following basal ganglia damage are mostly used. Our laboratory has shown that S-adenosyl-methionine (SAM) injections into the brain of rats reliably produced tremors, rigidity, hypokinesia, and abnormal posture. Thus, SAM-induced tremors, when distinguished from nontremor activities, has the potential as a model for testing anti-PD agents. Tremor Monitor-recorded activity profiles of the rats injected with SAM showed low-amplitude signals interlaced with high-amplitude bursts of tremor episodes. Control activities were of low-medium amplitudes with no such patterns. The number of real and apparent episodes detected over 20 min were 92 +/- 12 and 84 +/- 14 lasting 470 +/- 50 and 210 +/- 50 s, indicating mean durations of 5.1, and 2.4 s, frequencies of 12 +/- 0.1 and 11 +/- 0.2 Hz, cycles (waves) per episode of 54 +/- 6 and 19 +/- 2 and amplitudes of 42.3 +/- 5 and 19.8 +/- 1 for the SAM-treated and control rats, respectively. The nontremor activities of rats injected with phosphate-buffered saline were distinguished and eliminated by raising the minimum amplitude and number of cycles to 20. This procedure is being enhanced for screening antitremor agents and for elucidating the possible mechanism for Parkinsonism.
机译：震颤是帕金森氏病（PD）最明显的症状，应作为模型进行评估的适当参数。缺乏可靠的PD震颤模型和方法来区分震颤和非震颤运动意味着大多数非震颤行为，例如基底神经节损伤后的旋转。我们的实验室表明，向大鼠的大脑中注射S-腺苷甲硫氨酸（SAM）可以可靠地产生震颤，僵硬，运动不足和姿势异常。因此，与非震颤活动区分开时，SAM诱发的震颤具有作为测试抗PD药物的模型的潜力。震颤监测器记录的注射SAM的大鼠的活动状况显示，低振幅信号与高振幅震颤发作交错。对照活动的幅度中等偏低，没有这种模式。在20分钟内检测到的真实和明显发作的次数分别为92 +/- 12和84 +/- 14，持续470 +/- 50和210 +/- 50 s，指示平均持续时间为5.1和2.4 s，频率为12 +/- 0.1和11 +/- 0.2 Hz，对于SAM处理过的和SAM，每集的周期（波）为54 +/- 6和19 +/- 2，幅度为42.3 +/- 5和19.8 +/- 1对照大鼠。通过将最小振幅和周期数提高到20，可以区分并消除注射磷酸盐缓冲盐水的大鼠的非震颤活动。此程序正在增强，以筛选抗震颤剂并阐明帕金森氏症的可能机制。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号