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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Sustained behavioral stimulation following selective activation of group I metabotropic glutamate receptors in rat striatum.
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Sustained behavioral stimulation following selective activation of group I metabotropic glutamate receptors in rat striatum.

机译：选择性激活大鼠纹状体中的I类代谢型谷氨酸受体后，持续的行为刺激。

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Group I metabotropic glutamate receptors (mGluRs) are densely expressed in the medium-sized spiny projection neurons of striatum. Activation of this group of the mGluRs modifies neuronal physiology through stimulation of phosphoinositide hydrolysis and intracellular Ca(2)+ release. Unlike the ionotropic glutamate receptors that mediate rapid synaptic transmission, activation of the mGluRs produces long-lasting actions brought about by modulation of activities of intracellular effectors. In this study, the role of the group I mGluRs in the modulation of extrapyramidal motor function was examined using a group I selective agonist, 3, 5-dihydroxyphenylglycine (DHPG), in chronically cannulated rats. Bilateral injections of DHPG at a series of subtoxic doses (20, 40, 80, and 160 nmol) into the central part of the dorsal striatum produced hyperlocomotion and a unique stereotypical behavior (spontaneous and repetitive twitching movement of the head and forepaws) in a dose-dependent manner. The characteristic twitchy behavior usually commenced 30 min to 1 h, and could last as long as 10 to 12 h, after a single injection of the group I agonist. The behavioral responses to DHPG administration were markedly antagonized by intrastriatal injection of the group I antagonist PHCCC (10 nmol), but not the group II/III antagonist MSOPPE (10 nmol). Intrastriatal administration of 20 nmol dantrolene, an inhibitor of intracellular Ca(2)+ mobilization, also prevented DHPG-stimulated motor activities. However, blockade of dopamine D(1) receptors with systemic administration of SCH-23390 (0.1 mg/kg, SC) did not alter the ability of DHPG to provoke behavioral activities. These data indicate that selective activation of the DHPG-sensitive group I mGluRs in the striatum can produce long-lasting stimulation of motor activity. DHPG-induced motor stimulation involves the mobilization of intracellular Ca(2)+ stores, but appears to be independent of D(1) dopaminergic transmission.
机译：第一组代谢型谷氨酸受体（mGluRs）在纹状体的中型多刺投射神经元中密集表达。激活这一类的mGluRs通过刺激磷酸肌醇水解和细胞内Ca（2）+释放来修饰神经元生理。与介导快速突触传递的离子型谷氨酸受体不同，mGluRs的激活产生了通过调节细胞内效应子的活性而带来的持久作用。在这项研究中，使用I组选择性激动剂3，5-二羟基苯基甘氨酸（DHPG）在慢性插管大鼠中检查了I组mGluRs在锥体外运动功能调节中的作用。在背侧纹状体中央向一侧注射一系列次毒性剂量（20、40、80和160 nmol）的DHPG产生超速运动和独特的刻板行为（头部和前爪的自发性和反复性抽搐运动）。剂量依赖性。单次注射I组激动剂后，典型的抽搐行为通常在30分钟到1小时开始，并且可能持续长达10到12小时。纹状体内注射I组拮抗剂PHCCC（10nmol），而不是II / III组拮抗剂MSOPPE（10nmol），显着拮抗对DHPG给药的行为反应。纹状体内20 nmol dantrolene，细胞内Ca（2）+动员的抑制剂，也可以防止DHPG刺激运动活动。但是，通过全身施用SCH-23390（0.1 mg / kg，SC）来阻断多巴胺D（1）受体并不能改变DHPG激发行为活性的能力。这些数据表明，纹状体中的DHPG敏感的I型mGluRs的选择性激活可以产生对运动活动的持久刺激。 DHPG诱导的运动刺激涉及细胞内Ca（2）+商店的动员，但似乎独立于D（1）多巴胺能传递。

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