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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Lead and ethanol coexposure: implications on the dopaminergic system and associated behavioral functions.
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Lead and ethanol coexposure: implications on the dopaminergic system and associated behavioral functions.

机译：铅和乙醇共同暴露：对多巴胺能系统和相关行为功能的影响。

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The present investigation involves ethanol's effects on the lead-induced alterations in the dopaminergic system. Ethanol, at a dose of 3 g/kg body weight for 8 weeks, resulted in a marked increase in the accumulation of lead in the blood and brain of animals receiving 50 mg lead/kg body weight. Levels of dopamine were found to decrease significantly, and were accompanied with increased norepinephrine levels in lead and ethanol coexposed animals. Uptake of tyrosine as well as the activities of tyrosine hydroxylase and monoamine oxidase were seen to increase significantly in lead as well as ethanol-treated animals, and these were increased to a greater extent when animals were administered lead and ethanol simultaneously. Dopamine receptor binding studies revealed a significant elevation in the number of binding sites in lead and ethanol-coexposed animals. The altered dopaminergic functions were reflected by the neurobehavioral deficits in terms of motor incoordination, aggressiveness, and hyperactivity of animals exposed to lead, the effect being more pronounced in lead- and ethanol-coexposed animals. In brief, results of this study suggests that ethanol potentiates lead-induced cellular damage at the neurochemical and neurobehavioral level.
机译：本研究涉及乙醇对多巴胺能系统中铅诱导的改变的影响。乙醇以3 g / kg体重的剂量持续8周，导致铅在以50 mg铅/ kg体重存在的动物的血液和大脑中的积累显着增加。发现在铅和乙醇共暴露的动物中，多巴胺水平显着降低，并伴有去甲肾上腺素水平升高。在铅和乙醇处理的动物中，酪氨酸的摄取以及酪氨酸羟化酶和单胺氧化酶的活性均显着增加，而在同时施用铅和乙醇的动物中，酪氨酸的摄取显着增加。多巴胺受体结合研究表明铅和乙醇共同暴露的动物中结合位点的数量显着增加。多巴胺能功能的改变反映在接触铅的动物的运动不协调，侵略性和活动亢进方面，表现为神经行为缺陷，这种作用在铅和乙醇共同暴露的动物中更为明显。简而言之，这项研究的结果表明乙醇在神经化学和神经行为水平上增强了铅诱导的细胞损伤。

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