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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Hypoexpression of benzodiazepine receptors in the amygdala of neophobic BALB/c mice compared to C57BL/6 mice.
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Hypoexpression of benzodiazepine receptors in the amygdala of neophobic BALB/c mice compared to C57BL/6 mice.

机译：与C57BL / 6小鼠相比，新恐惧症BALB / c小鼠的杏仁核中苯二氮卓受体的低表达。

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摘要

The distribution of benzodiazepine receptors in the brain of neophobic BALB/c mice was studied by autoradiographic analysis using [3H]-diazepam and compared to that of the same receptors of the "nonemotional" C57BL/6 mice. This technique revealed no significant interstrain difference except for a lower density of diazepam binding sites in the amygdala of BALB/c mice. Therefore, the expression of benzodiazepine receptors in the amygdala of the two strains of mice were quantified by binding studies on brain membranes. The amygdala of BALB/c mice exhibited a fivefold decrease in the density of benzodiazepine receptors compared to C57BL/6 mice. These results suggest that the trait anxiety (neophobia) that characterizes BALB/c mice could be due, at least in part, to a genetic modulation of benzodiazepine receptor expression in the amygdala, a structure known to be strongly involved in fear behavior.
机译：通过使用[3H]-地西am的放射自显影分析研究了新厌氧BALB / c小鼠脑中苯并二氮杂receptor受体的分布，并将其与“非情感性” C57BL / 6小鼠的相同受体进行了比较。该技术没有显示出显着的株间差异，除了BALB / c小鼠杏仁核中地西epa结合位点的密度较低。因此，通过在脑膜上的结合研究定量了这两种小鼠的杏仁核中苯并二氮杂receptor受体的表达。与C57BL / 6小鼠相比，BALB / c小鼠的杏仁核显示苯二氮杂pine受体的密度降低了五倍。这些结果表明，表征BALB / c小鼠的特征性焦虑（新恐惧症）可能至少部分归因于杏仁核中苯二氮卓类受体表达的遗传调节，这种结构已知与恐惧行为密切相关。

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