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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Ovarian hormone replacement affects cocaine-induced behaviors in ovariectomized female rats.
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Ovarian hormone replacement affects cocaine-induced behaviors in ovariectomized female rats.

机译：卵巢激素替代影响可卡因在卵巢切除雌性大鼠中的行为。

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To determine whether cocaine-induced behavioral alterations are modulated by ovarian hormones, ovariectomized rats were randomly assigned to one of two drug treatment conditions: "binge" cocaine (three 15-mg/kg intraperitoneal (ip) injections, 1 h apart) or saline administration; and four hormone pretreatment sub-groups: vehicle control, estrogen, progesterone, or estrogen+progesterone. Cocaine-treated animals displayed more locomotor activity than saline-treated animals and locomotor activity was higher after the third injection than after the first two injections. When analyzed according to hormone group, the administration of estrogen+progestrone suppressed cocaine-induced locomotion after the first injection; this effect was significant when compared to estrogen-pretreated animals. While in each condition cocaine-treated animals displayed significantly higher stereotypic activity than saline-treated animals, in the estrogen+progesterone replacement group, there was more activity after the second injection of cocaine than after the first. Interestingly, animals in the estrogen+progesterone group had significantly lower plasma levels of the cocaine metabolite, benzoylecgonine, than animals in the progesterone or estrogen groups. These results extend our earlier findings in the intact female rat, which suggest an interaction between the endocrine environment, cocaine metabolism, and cocaine-induced behaviors. These effects may underlie reported sex and estrous cycle differences in cocaine-induced behavioral activity.
机译：为了确定可卡因诱导的行为改变是否受卵巢激素调节，将卵巢切除的大鼠随机分配至以下两种药物治疗条件之一：“可卡因”可卡因（三种15 mg / kg腹膜内（ip）注射，间隔1 h）或生理盐水行政;和四个激素预处理子组：媒介物对照，雌激素，孕酮或雌激素+孕酮。可卡因治疗的动物比生理盐水治疗的动物表现出更大的运动能力，并且第三次注射后的运动能力比前两次注射后的更高。根据激素组进行分析时，第一次注射后，雌激素+孕酮的给药抑制了可卡因引起的运动。与雌激素预处理的动物相比，这种作用是显着的。尽管在每种情况下，可卡因治疗的动物都比生理盐水治疗的动物表现出明显更高的定型活性，但在雌激素+孕激素替代组中，第二次注射可卡因后的活动比第一次注射后的活动多。有趣的是，雌激素+孕酮组的动物的血浆可卡因代谢物苯甲酰芽子碱的血浆水平明显低于孕酮或雌激素组的动物。这些结果扩展了我们在完整雌性大鼠中的早期发现，表明内分泌环境，可卡因代谢和可卡因诱导的行为之间存在相互作用。这些影响可能是可卡因诱发的行为活动中报道的性别和发情周期差异的基础。

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