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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Effects of drugs acting as histamine releasers or histamine receptor blockers on an experimental anxiety model in mice.
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Effects of drugs acting as histamine releasers or histamine receptor blockers on an experimental anxiety model in mice.

机译：充当组胺释放剂或组胺受体阻滞剂的药物对小鼠实验性焦虑模型的影响。

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Experimental anxiety in mice was evaluated using a light/dark test at 60 min after injection of various histaminergics. Thioperamide, a histamine H(3) receptor inhibitor (5-20 mg/kg, intraperitoneal [IP]), Compound 48/80, a mast cell degranulator (0.1-10 microg/2 microl, intracerebroventricularly [ICV]), mepyramine, a histamine H(1) receptor antagonist (0.1-10 &mgr;g/2 microl, ICV) or cimetidine, a histamine H(2) receptor antagonist (0.1-10 microg/2 microl, ICV) alone did not affect the locomotive activity, the time spent in the light zone, and number of shuttle crossings in the light/dark test. However, the time spent in the light zone and the number of shuttle crossings significantly decreased only when cimetidine (0.1-10 microg/2 microl, ICV) was co-treated with either thioperamide (10 mg/10 ml/kg, IP) or Compound 48/80 (1.0 microg/2 microl, ICV). The decrease in these behavioral parameters suggests induced experimental anxiety in mice. The experimental anxiety was antagonized by mepyramine (10 microg/2 microl, ICV). These results suggest that not only neuronal histamine release induced by thioperamide but also non-neuronal (mast cells) histamine release induced by Compound 48/80 play an important role in inducing experimental anxiety via post-synaptic H(1) and H(2) receptors. In addition, it is likely that the anxiety may be mediated by the stimulation of H(1) receptors, while H(2) receptors may inhibit the anxiety produced by the activation of H(1) receptors.
机译：在注射各种组胺药后60分钟，使用明/暗测试评估小鼠的实验性焦虑。硫菌酰胺，组胺H（3）受体抑制剂（5-20​​ mg / kg，腹膜内[IP]），化合物48/80，肥大细胞脱粒剂（0.1-10 microg / 2 microl，脑室内[ICV]），美吡拉敏，组胺H（1）受体拮抗剂（0.1-10微克/ 2微升，ICV）或西咪替丁，仅组胺H（2）受体拮抗剂（0.1-10微克/ 2微升，ICV）不会影响机车活动，在亮区中花费的时间以及明暗测试中穿梭点的数量。但是，仅当将西咪替丁（0.1-10微克/ 2微升，ICV）与硫代过酰胺（10毫克/ 10毫升/千克，IP）共同处理时，在亮区所花费的时间和穿梭穿越次数才显着减少。化合物48/80（1.0微克/ 2微升，ICV）。这些行为参数的降低表明在小鼠中诱发了实验性焦虑。美吡拉敏（10微克/ 2微升，ICV）可对抗实验性焦虑。这些结果表明，不仅硫磺酰胺诱导的神经元组胺释放，而且化合物48/80诱导的非神经元（肥大细胞）组胺释放在通过突触后H（1）和H（2）诱导实验性焦虑中也起重要作用。受体。另外，焦虑症可能是由H（1）受体的刺激介导的，而H（2）受体则可能抑制H（1）受体的激活所产生的焦虑。

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