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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Congenic strains developed for alcohol- and drug-related phenotypes.
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Congenic strains developed for alcohol- and drug-related phenotypes.

机译：针对酒精和药物相关表型开发的同类菌株。

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摘要

Quantitative trait loci (QTLs) for many alcohol- and drug-related traits have been mapped using well-accepted mapping techniques. The ultimate goal of gene identification necessitates confirmation of the QTL and reduction of the interval surrounding the QTL; both can be accomplished in congenic strains. These strains carry a chromosomal region introgressed from a donor strain onto the genetic background of a second, recipient strain. Multiple generations of backcrossing reduce the unlinked donor genome to less than 0.1%. Then, phenotypic comparisons between mice congenic for the donor region and controls from the recipient strain allow confirmation of the QTL effect. Animals with recombinations in the donor region can be used to generate interval-specific congenic recombinant lines. Numerous congenic strains are currently being developed in which chromosomal regions carrying QTLs for alcohol- and drug-related traits have been transferred from one strain onto a second strain. The purpose of this review is to summarize the chromosomal regions, donor and recipient strains, and results obtained from these congenics. Most researchers developing such strains are willing to share these resources to facilitate localization of the genetic bases of other phenotypes.
机译：许多酒类和药物相关性状的数量性状基因座（QTL）已使用公认的作图技术进行了作图。基因鉴定的最终目的是确认QTL和缩短QTL的间隔。两者都可以在同系菌株中完成。这些菌株带有从供体菌株渗入到第二个受体菌株的遗传背景中的染色体区域。多代回交将未连接的供体基因组减少到小于0.1％。然后，在供体区同基因小鼠与受体品系对照之间的表型比较可以确认QTL的作用。供体区域重组的动物可用于产生间隔特异性的同基因重组品系。当前正在开发许多同系菌株，其中携带有与酒精和药物相关性状的QTL的染色体区域已从一种菌株转移到另一种菌株上。本文的目的是总结染色体区域，供体和受体菌株，以及从这些同系基因获得的结果。研发此类菌株的大多数研究人员愿意共享这些资源，以促进其他表型遗传碱基的定位。

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