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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >The effects of prenatal cocaine exposure and genotype on the ultrasonic calls of infant mice.
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The effects of prenatal cocaine exposure and genotype on the ultrasonic calls of infant mice.

机译：产前可卡因暴露和基因型对婴儿小鼠超声检查的影响。

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摘要

Estimates are that as many as 44,000 humans are exposed to cocaine in utero per year. In this study we examined the effects of prenatal cocaine exposure on one aspect of the mother-infant relationship in mice, infant ultrasonic calls. We mated C57BL/10J female mice with males of three different inbred strains (producing pups of three different F(1) genotypes). We injected those females, subcutaneously, with saline or 20 mg/kg of cocaine hydrochloride on days 7-17 of gestation. That dosage did not compromise mother or pup viability, weight, or gestation length. On postnatal days 2-4, we recorded and measured the calls of pups while they were separated from their nest and slightly chilled. The results indicate changes in the ultrasonic calls as a function of cocaine and genotype. Overall, cocaine reduced the number of calls and increased the beginning pitch of calls. Pups of one genotype, a C57BL/10JxSJL/J hybrid were unaffected by cocaine exposure. The effects of cocaine, though reliable, were small, explaining only 1-2% of the total sum of squares. The size of the effect is in part due to the differential effect of cocaine on different genotypes.
机译：据估计，每年有多达44,000人在子宫内接触可卡因。在这项研究中，我们检查了产前可卡因暴露对小鼠母婴关系的一个方面（婴儿超声）的影响。我们将C57BL / 10J雌性小鼠与三种不同自交系的雄性交配（产生三种不同F（1）基因型的幼仔）。在妊娠的第7至17天，我们向这些雌性皮下注射了生理盐水或20 mg / kg的可卡因盐酸盐。该剂量不会影响母亲或幼崽的生存能力，体重或妊娠长度。在出生后的第2-4天，我们记录并测量了幼崽从巢中分离出来并稍微冷藏后的声音。结果表明，超声检查中可卡因和基因型的变化。总体而言，可卡因减少了通话次数并增加了通话的开始音调。可卡因暴露不影响一种基因型的幼犬C57BL / 10JxSJL / J杂种。可卡因的作用虽然可靠，但影响很小，仅解释了平方和的1-2％。效果的大小部分是由于可卡因对不同基因型的不同作用。

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