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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Ketamine blocks a taste-mediated conditioned motor response in perinatal rats.
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Ketamine blocks a taste-mediated conditioned motor response in perinatal rats.

机译：氯胺酮在围产期大鼠中阻断了味觉介导的条件性运动反应。

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摘要

Brain N-methyl-D-aspartate (NMDA) glutamate receptors have been implicated as important mediators of both learning and neuronal development. The current study investigated how ketamine HCl (a well-known NMDA-receptor blocking drug) would influence taste-mediated conditioned motor responses in perinatal rats. Dams pregnant with E19 rat fetuses were injected with 0, 50, or 100 mg/kg ketamine HCl (IP). One-half hour later, a reversible spinal block was performed on the dam, and fetuses received an oral injection of 10 microl 0.3% Saccharin (SAC) or water while in utero. After the oral injection, fetuses received either saline or LiCl (81 mg/kg, IP). The uterus was replaced and, 2 days later (E21), rats received oral lavage with SAC. Rats in other litters were born via a normal vaginal delivery and were exposed to SAC on postnatal day 3 (P3). Observations of motor responses were recorded immediately after the oral lavage of SAC. If SAC had been paired with LiCl in utero, both E21 and P3 pups exhibited a conditioned suppression of orofacial movements (compared to controls). Both doses of ketamine significantly attenuated this taste-mediated conditioned motor response. These data reinforce the current conception of the fetus and neonate as sophisticated sensors and responders to the uterine and extrauterine environment. Further, our findings indicate a role for NMDA receptors in the formation of a conditioned motor response in fetal rats.
机译：脑N-甲基-D-天冬氨酸（NMDA）谷氨酸受体被认为是学习和神经元发育的重要介质。目前的研究调查了氯胺酮盐酸盐（一种著名的NMDA受体阻断药物）如何影响围产期大鼠中味觉介导的条件性运动反应。给怀有E19大鼠胎儿的母鼠注射0、50或100 mg / kg氯胺酮HCl（IP）。一个半小时后，在大坝上进行了可逆的脊柱阻滞，胎儿在子宫内时口服了10微升0.3％糖精（SAC）或水。口服后，胎儿接受生理盐水或LiCl（81 mg / kg，IP）。更换子宫，两天后（E21），大鼠接受SAC灌洗。其他窝的大鼠通过正常的阴道分娩出生，并在出生后第3天（P3）暴露于SAC。口服SAC后立即记录运动反应的观察结果。如果SAC已与子宫内的LiCl配对，则E21和P3幼仔均表现出条件性抑制口颌运动（与对照组相比）。两种剂量的氯胺酮均显着减弱了这种味觉介导的条件性运动反应。这些数据强化了胎儿和新生儿作为子宫和宫外环境的复杂传感器和反应器的当前观念。此外，我们的发现表明NMDA受体在胎鼠中条件性运动反应的形成中具有作用。

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