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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Testosterone is required for corticosteroid-binding globulin upregulation by morphine to be fully manifested.
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Testosterone is required for corticosteroid-binding globulin upregulation by morphine to be fully manifested.

机译：要充分表现出吗啡上皮激素结合球蛋白上调所需要的睾丸激素。

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We previously reported that morphine increases the concentration of corticosteroid-binding globulin (CBG) in blood of male, but not female, rats. This pronounced sexual dimorphism suggested that CBG upregulation by morphine might be androgen-dependent. In the current studies, we found that castration, whether performed just before or just after puberty or in adulthood, increased the concentration of CBG in adult male rats. Naltrexone did not prevent this increase and, therefore, it does not appear to be attributable to the release of endogenous opioids. Exposure to morphine for 1 week in adulthood increased ( approximately 100%) the concentration of CBG in intact, i.e., sham-castrated, males. The CBG levels of castrated rats treated with morphine did not differ from those of intact rats treated with morphine. However, because castration increased the concentration of CBG, the difference between the placebo and morphine groups decreased with time after castration. At 4 weeks after castration, the difference between the morphine and placebo groups (19%) was no longer statistically significant. Testosterone replacement prevented the rise in CBG levels following castration and maintained the magnitude of the difference between placebo and morphine-treated rats within the normal range. Thus, testosterone appears necessary for morphine effects on CBG to be fully manifested.
机译：我们先前曾报道吗啡会增加雄性大鼠血液中皮质类固醇结合球蛋白（CBG）的浓度，但不会增加雌性大鼠血液中的浓度。这种明显的性二态性表明吗啡对CBG的上调可能是雄激素依赖性的。在当前的研究中，我们发现去势，无论是在青春期之前或之后进行，还是在成年期进行，都会增加成年雄性大鼠中CBG的浓度。纳曲酮不能阻止这种增加，因此，它似乎不归因于内源性阿片样物质的释放。成年后1周暴露于吗啡会增加（约100％）完整CBG的浓度，即假cast割的雄性。吗啡治疗的去势大鼠的CBG水平与吗啡治疗的完整大鼠的CBG水平无差异。但是，由于去势增加了CBG的浓度，所以安慰剂组与吗啡组之间的差异随着去势时间的延长而减小。去势后4周，吗啡组与安慰剂组之间的差异（19％）不再具有统计学意义。睾丸激素替代可防止去势后CBG水平升高，并使安慰剂和吗啡治疗的大鼠之间的差异幅度保持在正常范围内。因此，睾丸激素似乎是充分证明吗啡对CBG的作用所必需的。

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