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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Gender and gonadal hormone effects in the olfactory bulbectomy animal model of depression.
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Gender and gonadal hormone effects in the olfactory bulbectomy animal model of depression.

机译：嗅球切除术抑郁动物模型中的性别和性腺激素作用。

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摘要

Major depressive disorder (MDD) affects women to a greater extent then men; however, the few studies that have examined the role of gender in an animal model of depression have shown inconsistent results. The purpose of the present study was to determine if the gonadal hormone milieu of the animal modulated behavioral changes following olfactory bulbectomy (OBX), a well-documented animal model of depression. Body weight, sucrose preference levels and open-field activity levels were measured once a week for a period of 2 weeks in gonadally intact and gonadectomized male and female rats. Following these baseline measurements, animals underwent either OBX or sham surgery. Body weight, sucrose preference and activity levels were assessed for 4 weeks post-OBX surgery. OBX-gonadectomized animals exhibited higher activity levels than OBX gonadally intact and control animals. This effect of gonadectomy was more robust in males. OBX-females (both intact and gonadectomized) exhibited significantly lower sucrose preference levels than OBX-males (both intact and gonadectomized) and control animals. These results suggest that the gonadal hormone milieu of the animal plays a role in modulating sucrose preference and activity levels following OBX.
机译：重度抑郁症（MDD）对女性的影响要大于男性。然而，少数研究了性别在抑郁症动物模型中的作用的研究结果却不一致。本研究的目的是确定嗅觉性球囊切除术（OBX）后该动物的性腺激素环境是否能调节行为变化，这是一个有据可查的抑郁症动物模型。在性腺完整和经性腺切除的雄性和雌性大鼠中，每周两次测量体重，蔗糖偏爱水平和开阔地域活动水平，持续2周。在这些基线测量之后，对动物进行OBX或假手术。在OBX手术后4周评估体重，蔗糖偏爱和活性水平。 OBX性腺切除的动物显示出比性腺完整和对照动物更高的活性水平。男性性腺切除术的这种作用更为强烈。 OBX-雌性（完整和性腺切除）均显示出比OBX-雄性（完整和性腺切除）及对照动物低得多的蔗糖偏爱水平。这些结果表明，OBX后，动物的性腺激素环境在调节蔗糖偏好和活性水平中起作用。

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