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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Prenatal nicotine exposure: effects on locomotor activity and central (125I)alpha-BT binding in rats.
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Prenatal nicotine exposure: effects on locomotor activity and central (125I)alpha-BT binding in rats.

机译：产前尼古丁暴露：对大鼠运动活动和中枢（125I）alpha-BT结合的影响。

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摘要

Maternal smoking during pregnancy or in utero exposure of the fetus to nicotine may result in learning difficulties and hyperactivity in the child. To elucidate possible involvement of the alpha(7) nicotinic receptor subtype in these behavioral impairments, pregnant dams were treated with nicotine (9 mg/kg/day) via osmotic minipumps throughout gestation. Male offspring were weaned at postnatal day 18, and were tested for locomotor activity at postnatal days 20-24. Pups were sacrificed on postnatal day 36-38 and 18 discrete brain areas were analyzed for [125I]alpha-bungarotoxin (alpha-BT) binding by quantitative autoradiography. Prenatal nicotine caused an elevation in locomotor activity (vertical movements) in offspring. [125I]alpha-BT binding was significantly reduced in the hippocampal CA1 region (29%), dentate gyrus (22%), and medial geniculate nucleus (29%). These findings suggest that some of the behavioral abnormalities induced by prenatal nicotine exposure may be due to a reduction of alpha(7) nicotinic receptors in discrete brain regions.
机译：孕妇在怀孕期间或胎儿在子宫内暴露于尼古丁时吸烟可能会导致孩子学习困难和活动过度。为了阐明在这些行为障碍中可能存在α（7）烟碱样受体亚型，在整个妊娠过程中，通过渗透性微型泵用尼古丁（9 mg / kg /天）对怀孕的水坝进行处理。雄性后代在产后第18天断奶，并在产后第20-24天进行运动能力测试。在出生后第36-38天将幼鼠处死，并通过定量放射自显影术分析18个离散的大脑区域的[125I]α-真菌毒素（α-BT）结合。产前尼古丁引起后代运动活动（垂直运动）升高。 [125I]α-BT结合在海马CA1区（29％），齿状回（22％）和内侧膝状核（29％）显着降低。这些发现表明，产前尼古丁暴露引起的某些行为异常可能是由于离散脑区域中的α（7）烟碱受体减少所致。

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