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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Antiepileptogenic properties of phenobarbital: behavior and neurochemical analysis.
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Antiepileptogenic properties of phenobarbital: behavior and neurochemical analysis.

机译：苯巴比妥的抗癫痫药特性：行为和神经化学分析。

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Chronic in vivo models of epilepsy provide a suitable strategy for quantifying epileptogenesis, as well as investigating neurochemical changes associated with neuronal plasticity that leads to seizuring conditions. The aim of this paper was to investigate antiepileptogenic properties of phenobarbital, focusing on the neurochemical changes associated with repeated seizures induced by low convulsive dose of pentylenetetrazol (PTZ) (60 mg/kg, sc) in mice. Phenobarbital (10 and 30 mg/kg, ip) significantly diminished the severity of seizures induced by PTZ. Repeated PTZ administration was associated with an increase in [3H]glutamate binding (B(max) 196.6+/-10.2 pmol/mgxcontrol B(max) 137.7+/-17.0 pmol/mg). Regarding NMDA receptors, repeated PTZ administration was likewise associated with an increase in [3H]MK-801 binding (0.55+/-0.02 pmol/mgxcontrol 0.32+/-0.01 pmol/mg). In addition, phenobarbital (10 mg/kg) prevented the increase in [3H]glutamate binding (B(max) 133.7+/-11.4 pmol/mg), as well as in [3H]MK-801 binding (phenobarbital 10 and 30 mg/kg, 0.33+/-0.01 and 0.34+/-0.01 pmol/mg, respectively). This study reveals an interesting capability of phenobarbital in interfering with the establishment of both the behavioral expression and associated neurochemical changes induced by the repeated administration of low convulsive dose of PTZ, which may be important in the context of preventing epileptogenesis.
机译：慢性癫痫的体内模型提供了量化癫痫发生以及研究与神经元可塑性相关的神经化学变化（导致癫痫发作的条件）的合适策略。本文的目的是研究苯巴比妥的抗癫痫发生特性，重点研究与低惊厥剂量戊四氮（PTZ）（60 mg / kg，sc）诱发的小鼠反复发作相关的神经化学变化。苯巴比妥（10和30 mg / kg，腹腔注射）可显着降低PTZ诱发的癫痫发作的严重程度。重复施用PTZ与[3H]谷氨酸结合增加（B（最大）196.6 +/- 10.2 pmol / mgx对照B（最大）137.7 +/- 17.0 pmol / mg）有关。关于NMDA受体，重复施用PTZ同样与[3H] MK-801结合增加（0.55 +/- 0.02pmol / mgx对照0.32 +/- 0.01pmol / mg）有关。此外，苯巴比妥（10 mg / kg）阻止[3H]谷氨酸结合（B（max）133.7 +/- 11.4 pmol / mg）以及[3H] MK-801结合（苯巴比妥10和30）的增加。毫克/千克，0.33 +/- 0.01和0.34 +/- 0.01 pmol / mg）。这项研究揭示了苯巴比妥在干扰行为表达和相关神经化学变化的建立方面的有趣能力，这些行为是由反复服用低惊厥剂量的PTZ引起的，这在预防癫痫发生的背景下可能很重要。

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