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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Kappa opioid-induced diuresis in female vs. male rats.
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Kappa opioid-induced diuresis in female vs. male rats.

机译：卡伯阿片类药物诱导的雌性和雄性大鼠利尿。

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摘要

Kappa opioid agonists may produce dissimilar discriminative and analgesic effects in female vs. male subjects. The present study was conducted to determine whether a prototypic physiological effect of kappa agonists--diuresis--also differs between the sexes. When data were not corrected for individual differences in body weight, the kappa agonists U69,593 (0.03-3.0 mg/kg), U50,488 (0.3-10 mg/kg), (-)-bremazocine (0.001-0.1 mg/kg) and (-)-pentazocine (1-10 mg/kg), as well as a nonopioid diuretic, furosemide (1-10 mg/kg) produced significantly greater diuresis in normally hydrated, age-matched males than females; however, there was no sex difference in the diuretic effect of butorphanol (0.3-3.0 mg/kg), or in the antidiuretic effect of the mu agonist morphine (1.0-5.6 mg/kg, in water-loaded rats). In contrast, when data were corrected for individual difference in body weight, U69,593, U50,488, (-)-bremazocine, (-)-pentazocine, and furosemide produced nearly equivalent diuresis/kg in females and males, whereas butorphanol produced slightly greater diuresis/kg, and morphine produced significantly less antidiuresis/kg, in females than males. U69,593-induced diuresis was highly similar in males and females of similar body weight (i.e., different ages). U69,593 effects were dose-dependently antagonized by the kappa antagonist nor-binaltorphimine in both sexes, indicating a common, kappa receptor-mediated mechanism of action. (-)-Bremazocine was slightly more potent in suppressing vasopressin in 24-h water-deprived males than females. These results suggest that the greater diuretic effects of kappa receptor-selective opioid agonists in male rats are primarily due to males' larger body size (greater body water) relative to age-matched females, but may also be attributed to slightly greater vasopressin suppression in males.
机译：Kappa阿片类激动剂可能在女性和男性受试者中产生不同的判别和镇痛作用。进行本研究是为了确定kappa激动剂的原型生理效应（利尿）在男女之间是否也有所不同。如果未针对体重的个体差异校正数据，则Kappa激动剂U69,593（0.03-3.0 mg / kg），U50,488（0.3-10 mg / kg），（-）-溴唑胺（0.001-0.1 mg / kg）和（-）-戊唑嗪（1-10 mg / kg）以及非阿片类利尿剂速尿（1-10 mg / kg）在正常水合的，与年龄匹配的男性中产生的利尿作用明显大于女性;然而，在负载水的大鼠中，布托啡诺的利尿作用（0.3-3.0 mg / kg）或亩激动剂吗啡的抗利尿作用（1.0-5.6 mg / kg）没有性别差异。相反，当对体重的个体差异进行校正后，雌性和雄性的U69,593，U50,488，（-）-溴咪唑嗪，（-）-戊唑嗪和呋塞米的利尿作用几乎相等/ kg，而布托啡诺则产生雌性的利尿/千克稍高，而吗啡产生的抗利尿/千克明显少于雄性。 U69,593引起的利尿在体重相似（即不同年龄）的男性和女性中非常相似。 U69,593的作用在两个性别中均受到kappa拮抗剂nor-binaltorphimine的剂量依赖性拮抗，表明了一种常见的kappa受体介导的作用机制。在24小时缺水的男性中，（-）-溴咪唑嗪在抑制血管加压素方面比女性稍强。这些结果表明，κ受体选择性阿片样物质激动剂对雄性大鼠的利尿作用更大，这主要是由于雄性相对于年龄相称的雌性而言，雄性的体型更大（体内水分更大），但也可能归因于雌性大鼠中加压素的抑制作用稍强。男性。

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