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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Developmental lead exposure in rats: is a behavioral sequel extended at F2 generation?
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Developmental lead exposure in rats: is a behavioral sequel extended at F2 generation?

机译：大鼠发育性铅暴露：行为续集在F2代会延长吗？

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摘要

Lead toxicity was studied in rats exposed from conception until weaning and assessed by monitoring offspring behavior in both the open field and elevated plus maze and by determining tissue lead in an assessment schedule extended to first (F1) and second (F2) generations. Dams utilized for the F1 generation were submitted to 750 ppm of lead (acetate) in drinking water during pregnancy and lactation. For F1 pups, behavioral alterations were not detected in the elevated plus maze, while in the open field, spontaneous locomotor activity as well as time of both grooming and rearing increased, while freezing time decreased in 30- and 90-day-old rats. Lead content was higher in tissues of 1- and 30-day-old pups. However, in 90-day-old rats, lead was detected only in the femur. F2 generation was lead-free but still presented alterations in both locomotor activity and grooming in 30- and 90-day-old pups. It appears that developmental lead exposure may cause behavioral effects during the developmental stage of the F1 generation, which remains throughout the animal's adult life as a sequel, regardless of lead accumulation, and is extended to the F2 generation of rats.
机译：研究了从受孕到断奶的大鼠的铅毒性，并通过在旷野和高架迷宫中监测后代行为并通过确定组织铅的评估方案进行评估，该评估方案已扩展到第一代（F1）和第二代（F2）。在怀孕和哺乳期间，将用于F1代的大坝中饮用水中的铅（乙酸盐）含量达到750 ppm。对于F1幼仔，在高架迷宫中未检测到行为改变，而在开阔田野中，在30日龄和90日龄大鼠中，自发运动能力以及梳理和饲养时间都增加了，而冻结时间却减少了。 1日龄和30日龄幼犬的组织中铅含量较高。但是，在90天大的大鼠中，仅在股骨中检测到铅。 F2代是无铅的，但在30日龄和90日龄的幼犬中，运动能力和修饰能力仍然存在变化。看来，铅暴露可能会在F1代的发育阶段引起行为影响，无论铅的积累如何，F1代的整个发育阶段都将其作为续集保留下来，并延续到F2代大鼠。

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