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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Perceptual and motor effects of morphine and buprenorphine in baboons.
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Perceptual and motor effects of morphine and buprenorphine in baboons.

机译：吗啡和丁丙诺啡在狒狒中的知觉和运动作用。

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The effects of morphine and buprenorphine on auditory perceptual discriminations and response latency ("reaction time") in baboons are compared. The task employed synthetic human vowel sounds that are readily generated in the laboratory, and closely approximate natural baboon "grunt" vocalizations [J. Acoust. Soc. Am. 101 (1997) 2951]. Baboons pressed a lever to produce one repeating "standard" vowel, and released the lever only when one of four other "comparison" vowels occasionally occurred in place of the standard vowel. The percentage of correct detections and median reaction time for each comparison were measured following intramuscular drug administrations of morphine (0.01-1.8 mg/kg) and buprenorphine (0.00032-0.032 mg/kg). Both morphine and buprenorphine impaired vowel discriminability, and greater impairments occurred for those comparison vowels that were more similar in formant structure to the standard vowel. Morphine increased reaction time in all baboons, and buprenorphine increased reaction time in two of three baboons. Morphine's perceptual effects occurred within 20-40 min following drug administration; buprenorphine's perceptual effects occurred 50-100 min following drug administration. Morphine and buprenorphine did not differ in the time course of their maximal reaction time effects. The results demonstrate that both morphine and buprenorphine can impair auditory discriminations involving human vowel sounds in baboons, as well as lengthen reaction times to the stimuli.
机译：比较了吗啡和丁丙诺啡对狒狒听觉知觉辨别力和反应潜伏期（“反应时间”）的影响。这项工作采用了在实验室中容易产生的合成人声元音，并非常接近自然狒狒的“咕gr声”发声[J． co Soc。上午。 101（1997）2951]。狒狒按下操纵杆以产生一个重复的“标准”元音，仅在偶尔出现另外四个“比较”元音之一代替标准元音时才释放操纵杆。在肌内注射吗啡（0.01-1.8 mg / kg）和丁丙诺啡（0.00032-0.032 mg / kg）后，对每个比较的正确检测百分比和中位反应时间进行了测量。吗啡和丁丙诺啡均会损害元音的可分辨性，并且那些共振峰结构与标准元音更相似的比较元音会出现更大的损伤。吗啡会增加所有狒狒的反应时间，丁丙诺啡会增加三个狒狒中的两个的反应时间。吗啡的知觉作用发生在给药后20-40分钟内;服用药物后50-100分钟，发生丁丙诺啡的知觉作用。吗啡和丁丙诺啡的最大反应时间影响在时间上没有差异。结果表明，吗啡和丁丙诺啡均会损害狒狒中涉及人元音的听觉辨别力，并会延长对刺激的反应时间。

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