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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Effects of insulin-produced hypoglycemia in combination with ethanol on spontaneous motor activity in rats.
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Effects of insulin-produced hypoglycemia in combination with ethanol on spontaneous motor activity in rats.

机译：胰岛素产生的低血糖症与乙醇联合对大鼠自发运动活动的影响。

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摘要

The hazardous consequences of drinking alcohol by persons receiving insulin treatment is indicated by clinical reports, but little controlled research has investigated the combination of hypoglycemia and ethanol intoxication. Ethanol's effect on spontaneous motor activity (SMA, detected by Opto-Varimax activity meters) in hypoglycemic (HG) rats was determined over a range of ethanol doses in two experiments. Combinations of insulin and ethanol were administered intraperitoneally to moderately food-deprived rats. Blood glucose was measured before and after a 30-min SMA-monitoring period. In Experiment 1, ethanol doses of 300, 600 and 1200 mg/kg were combined with insulin at doses 0.5 and 2 U/kg. A second experiment tested a narrower range of drug doses (ethanol 600 and 1200 mg/kg, insulin 1 U/kg) under slightly different procedures. After insulin treatment, blood-glucose levels dropped to approximately 40-60% of control levels and this HG was accompanied by decreased SMA. Ethanol did not influence blood-glucose levels, nor did it potentiate the HG produced by insulin. Combination of HG and the highest ethanol dose potentiated the SMA-depressant effect in both experiments, whereas lower ethanol doses partially reversed the suppression of motor activity in HG rats.
机译：临床报告表明，接受胰岛素治疗的人喝酒的危害性后果，但很少有对照研究调查低血糖和乙醇中毒的组合。在两个实验中，在一定剂量的乙醇中确定了低血糖（HG）大鼠中乙醇对自发运动活动（SMA，由Opto-Varimax活性计检测）的影响。腹膜内给予中度食物缺乏的大鼠胰岛素和乙醇的组合。在30分钟的SMA监测期间之前和之后测量血糖。在实验1中，将300、600和1200 mg / kg的乙醇剂量与0.5和2 U / kg的胰岛素剂量相结合。第二项实验在略有不同的程序下测试了较窄的药物剂量范围（乙醇600和1200 mg / kg，胰岛素1 U / kg）。胰岛素治疗后，血糖水平降至对照水平的约40-60％，并且该HG伴有SMA降低。乙醇不会影响血糖水平，也不会增强胰岛素产生的HG。在两个实验中，HG和最高乙醇剂量的组合均增强了SMA抑制作用，而较低的乙醇剂量则部分逆转了HG大鼠的运动抑制作用。

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