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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Acute exposure to a low or mild dose of soman: biochemical, behavioral and histopathological effects.
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Acute exposure to a low or mild dose of soman: biochemical, behavioral and histopathological effects.

机译：急性接触少量或中等剂量的梭曼：生化，行为和组织病理学影响。

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Effects of low to mild doses of soman on central and blood cholinesterase (ChE) activities and anxiety behavior were studied in mice 30 min, 24 h and 7 days after poisoning. At these two latter time points, histopathological consequences of soman intoxication were also studied. The 30-microg/kg dose of soman produced 30 min after intoxication, about 35% of central ChE inhibition, and an anxiolytic effect without toxic signs or histopathological changes. The 50-microg/kg dose of soman produced at the same time, about 56% of central ChE inhibition, slight clinical signs of poisoning without convulsions, an anxiogenic effect with a slight hypolocomotion but no brain damage. A mild dose of soman (90 microg/kg) produced at this same time point about 80% of central ChE inhibition, and led to ataxia and tremors in every mouse and to convulsions in some of them. Thirty minutes and 24 h after poisoning, the behavioral tests revealed neither anxiolytic nor anxiogenic responses despite a clear hypolocomotion. Only mice that experienced long-lasting convulsions developed neuropathological changes. The functional implication of our results, as well as the biological relevance of blood vs. brain ChE levels, as an index of intoxication severity are discussed.
机译：在中毒后30分钟，24小时和7天，研究了低剂量至中等剂量梭曼对中枢和血液胆碱酯酶（ChE）活性和焦虑行为的影响。在后两个时间点，还研究了梭曼中毒的组织病理学后果。梭曼以30微克/千克的剂量在中毒后30分钟产生，约占中枢ChE抑制量的35％，并且具有无毒迹象或组织病理学改变的抗焦虑作用。梭曼同时产生50微克/千克剂量的梭曼，约占中枢ChE抑制的56％，轻微中毒的临床体征，无惊厥，轻度低速运动但无脑损伤的抗焦虑作用。在同一时间点产生适量的梭曼（90 microg / kg）抑制中央ChE的80％，并导致每只小鼠共济失调和震颤，并在其中一些小鼠中引起惊厥。中毒后30分钟和24小时，尽管明显运动不足，但行为测试并未显示出抗焦虑或抗焦虑作用。只有经历长期惊厥的小鼠才会出现神经病理改变。讨论了我们研究结果的功能含义，以及血液与脑ChE水平的生物学相关性，作为中毒严重程度的指标。

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