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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Iron deficiency decreases dopamine D1 and D2 receptors in rat brain.
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Iron deficiency decreases dopamine D1 and D2 receptors in rat brain.

机译：铁缺乏会降低大鼠脑中的多巴胺D1和D2受体。

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Iron deficiency (ID) in early life is known to alter neurological development and functioning, but data regarding specific effects on dopamine biology are lacking. The objective of this study was to determine the extent of functional alterations in dopamine receptors in two dopaminergic tracts in young, growing, iron-deficient rats. Forty male and 40 female weanling Sprague-Dawley rats were fed either an iron-deficient (ID) diet or control (CN) diet for 6 weeks. ID decreased densities of D(1) and D(2) receptors in the caudate-putamen and decreased D(2) receptor densities in the nucleus accumbens. There were no apparent effects of ID on the affinities for the ligands in either receptor in several brain regions. In situ hybridization studies for both dopamine receptors revealed no significant effect of ID on mRNA expression for either receptor. Iron-deficient rats had a significantly higher ED(50) for raclopride-induced hypolocomotion in male and female rats compared to control rats of each sex. The loss of iron in the striatum due to dietary ID was significantly correlated with the decrease in D(2) receptor density; however, this relationship was not apparent in other brain regions. These experiments thus demonstrate abnormal dopamine receptor density and functioning in several brain regions that are related to brain regional iron loss. Importantly, the impact of ID on dopamine was more pronounced in males than females, demonstrating sex-related different sensitivities to nutrient deprivation.
机译：已知生命早期的铁缺乏症（ID）会改变神经系统的发育和功能，但缺乏有关对多巴胺生物学的特定影响的数据。这项研究的目的是确定年轻的，成长中的，铁缺乏的大鼠的两个多巴胺能束中多巴胺受体功能改变的程度。给40只雄性和40只雌性断奶Sprague-Dawley大鼠喂饲缺铁（ID）饮食或对照（CN）饮食6周。 ID降低了尾状丘脑中D（1）和D（2）受体的密度，伏隔核中D（2）受体的密度降低。 ID对几个大脑区域中任一受体的配体亲和力没有明显影响。两种多巴胺受体的原位杂交研究均显示ID对任一受体的mRNA表达均无明显影响。与每种性别的对照大鼠相比，铁缺乏的大鼠对雄性和雌性大鼠中雷氯必普诱导的运动不足的ED（50）明显更高。饮食ID引起纹状体中铁的损失与D（2）受体密度的降低显着相关。但是，这种关系在其他大脑区域中并不明显。因此，这些实验证明了与脑区域铁丢失有关的几个脑区域中异常的多巴胺受体密度和功能。重要的是，ID对多巴胺的影响在男性中比在女性中更为明显，这表明性别相关的对营养剥夺的不同敏感性。

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