• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Cortical (3H)ketanserin binding and 5-HT2A receptor-mediated behavioral responses in obese Zucker rats.
【24h】

Cortical (3H)ketanserin binding and 5-HT2A receptor-mediated behavioral responses in obese Zucker rats.

机译：肥胖的Zucker大鼠中皮质（3H）酮色林结合和5-HT2A受体介导的行为反应。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Past studies have indicated that genetically obese Zucker (fa/fa) rats are hypercorticoid, and that this neuroendocrine alteration plays a key role in the syndrome. In keeping with the proposal that glucocorticoids may upregulate central 5-HT2A receptors, we have studied the effects of acute and repeated 5-HT2A receptor stimulation by 1-(4-iodo-2,5-dimethoxyphenyl)-2-aminopropane (DOI) in lean and obese Zucker rats. Acute injection of DOI (2 mg/kg, SC) elicited a lower number of head shakes in obese rats compared to that measured in lean rats. Conversely, neither DOI-elicited decreases in food intakes and body weights nor cortical [3H]ketanserin binding were affected by obesity. In rats repeatedly pretreated with DOI, biochemical and functional indices of 5-HT2A receptor downregulation failed to reveal an effect of obesity. It is suggested that 5-HT2A receptor-mediated functions, but not their downregulation, may be differentially affected in the hypercorticoid obese Zucker rat.
机译：过去的研究表明，遗传性肥胖的祖克（fa / fa）大鼠是皮质激素，这种神经内分泌改变在该综合征中起关键作用。为了与糖皮质激素可能上调中央5-HT2A受体的提议保持一致，我们研究了1-（4-碘-2,5-二甲氧基苯基）-2-氨基丙烷（DOI）对急性和反复性5-HT2A受体刺激的影响在肥胖的Zucker肥胖大鼠中。与肥胖大鼠相比，肥胖大鼠的DOI急性注射（2 mg / kg，SC）引起的头摇次数更少。相反，肥胖不会影响DOI引起的食物摄入和体重下降，也不影响皮质[3H]酮色林的结合。在多次用DOI预处理的大鼠中，5-HT2A受体下调的生化和功能指标未能显示出肥胖的作用。提示5-HT2A受体介导的功能而不是其下调在高皮质类固醇肥胖Zucker大鼠中可能受到不同的影响。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号