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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Striatal dopamine-mediated motor behavior is altered following occlusion of the middle cerebral artery.
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Striatal dopamine-mediated motor behavior is altered following occlusion of the middle cerebral artery.

机译：大脑中动脉闭塞后，纹状体多巴胺介导的运动行为发生改变。

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摘要

Cerebral infarct (stroke) causes striatal damage with subsequent deterioration of sensorimotor and cognitive functions that may be mediated by the dopamine receptor system. In the present study, transient, focal ischemia was induced in Sprague-Dawley rats by middle cerebral artery occlusion. Ischemic animals exhibited significantly less dopamine antagonist (haloperidol)-induced catalepsy and more dopamine agonist (amphetamine)-induced hyperactivity than sham-operated animals. Younger ischemic animals showed more profound behavioral alteration but also displayed greater recovery over time than older ischemic animals. Histologic data revealed a lateral striatal lesion in all ischemic animals. These results place the striatal dopaminergic system as a possible strategic venue for the treatment of cerebral ischemia. In addition, aging is found to be a risk factor for stroke as noted in humans.
机译：脑梗塞（中风）引起纹状体损害，随后感觉运动和认知功能下降，可能由多巴胺受体系统介导。在本研究中，通过大脑中动脉闭塞在Sprague-Dawley大鼠中诱发短暂性局灶性局部缺血。与假手术动物相比，缺血性动物表现出的多巴胺拮抗剂（氟哌啶醇）引起的僵直症明显少，多巴胺激动剂（安非他明）引起的多动症明显。较年轻的缺血动物表现出更深刻的行为改变，但与较早的缺血动物相比，随着时间的流逝也显示出更大的恢复。组织学数据显示在所有缺血动物中均存在侧纹状体病变。这些结果使纹状体多巴胺能系统成为治疗脑缺血的可能战略场所。另外，如人类所述，发现衰老是中风的危险因素。

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