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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Higher environmental temperature-induced increase of body temperature: involvement of central opioidergic-GABAergic interaction.
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Higher environmental temperature-induced increase of body temperature: involvement of central opioidergic-GABAergic interaction.

机译：较高的环境温度引起的体温升高：参与中央阿片-GABA能相互作用。

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Exposure (2 h) of male albino rats to higher environmental temperature (HET, 40 degrees C) significantly increased the body temperature (BT). Administration of bicuculline (1 mg/kg, i.p.), physostigmine (0.2 mg/kg, i.p.), or their combination significantly raised the BT of normal rats (kept at 28 degrees C) or of HET-exposed rats. Atropine (5 mg/kg, i.p.) abolished the hyperthermic effect of bicuculline in normal and HET-exposed rats. The BT of normal and HET-exposed rat was increased with morphine (1 mg/kg, i.p.) and was reduced with naloxone (1 mg/kg, i.p.). Bicuculline or physostigmine-induced rise in BT of HET-exposed rats was potentiated following cotreatment of physostigmine with morphine. Atropine-induced hypothermia was abolished due to the cotreatment of atropine with morphine with physostigmine but was attenuated with atropine. In normal rats (kept at 28 degrees C), only atropine attenuated (morphine + bicuculline)-induced hyperthermia. L-Dopa + carbidopa or haloperidol did not significantly affect the BT of rats under similar conditions. These results suggest that short-term (2 h) exposure to HET activates the opioidergic neuron, which activates cholinergic activity through the inhibition of GABAergic system and, thus, enhances the BT.
机译：将雄性白化病大鼠暴露于较高的环境温度（HET，40摄氏度）（2小时）会显着提高体温（BT）。施用双小分子（1 mg / kg，腹腔内），毒扁豆碱（0.2 mg / kg，腹腔内）或它们的组合显着提高正常大鼠（保持在28摄氏度）或暴露于HET的大鼠的BT。阿托品（5 mg / kg，腹腔注射）消除了双瓜氨酸对正常和暴露于HET的大鼠的高热作用。正常和暴露于HET的大鼠的BT随吗啡（1 mg / kg，i.p.）升高而纳洛酮（1 mg / kg，i.p.）降低。毒扁豆碱与吗啡共同处理后，双小分子或毒扁豆碱诱导的HET暴露大鼠BT升高。由于将阿托品与吗啡和毒扁豆碱共同处理，从而消除了阿托品引起的体温过低，但被阿托品减弱了。在正常大鼠（保持在28摄氏度下）中，仅阿托品减弱（吗啡+双瓜氨酸）诱导的体温过高。在类似条件下，L-Dopa +卡比多巴或氟哌啶醇不会显着影响大鼠的BT。这些结果表明，短时（2 h）暴露于HET会激活视皮醇能神经元，并通过抑制GABA能系统激活胆碱能活性，从而增强BT。

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