• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Linopiridine (DUP 996; AVIVA): its effects in the Morris water escape tank and on retention of an incompletely acquired bar-press response in rodents.
【24h】

Linopiridine (DUP 996; AVIVA): its effects in the Morris water escape tank and on retention of an incompletely acquired bar-press response in rodents.

机译：Linopiridine（DUP 996; AVIVA）：其在莫里斯溢水槽中的作用以及对啮齿动物中不完全获得的压榨反应的保持作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The present study assessed the effects of linopirdine, a putative cognition-enhancing drug, on the acquisition and retention of a bar-press response [continuous reinforcement schedule (CRF)] in young Wistar rats. It was also investigated whether this substance influenced the acquisition and retention of a standard Morris water escape tansk by young NMRI mice and by young and old Wistar rats. Linopirdine was given subcutaneously (0.03, 0.1, 0.3, 1.0, or 3.0 mg/kg body wt.), 30 min before the first trial of a session and in one experiment immediately after the the last trial of each session. A probe trial was given after the last acquisition session. In the CRF task, linopirdine did not affect the response latency and the 24-h retention of young rats. None of the parameters investigated in the Morris maze, including the escape latency (the time the animals need to find the platform), was affected by linopirdine in the rat and mouse experiments. This was also true for performance in the probe trial: linopirdine treatment did not affect the bias of the animals for the quadrant in which the platform had been positioned during acquisition. Thus, we found no experimental evidence for the hypothesized action of linopirdine as a cognition enhancer.
机译：本研究评估了利诺吡丁（一种公认的增强认知能力的药物）对年轻Wistar大鼠获得和保持直板反应[持续增强时间表（CRF）]的影响。还调查了这种物质是否影响了幼小的NMRI小鼠以及幼老的Wistar大鼠对标准莫里斯泄水坦克的获取和保留。在一个疗程的第一次试验之前30分钟和在每个疗程的最后一个试验之后立即进行的一项实验中，皮下注射利诺吡定（0.03、0.1、0.3、1.0或3.0 mg / kg体重）。在最后一次获取会话之后进行了探查试验。在CRF任务中，利诺吡丁不影响幼鼠的反应潜伏期和24小时保留。在老鼠实验中，莫里斯迷宫中研究的所有参数（包括逃避潜伏期（动物需要找到平台的时间））均不受利尼吡丁的影响。探针试验中的性能也是如此：利诺吡丁治疗对采集过程中平台所处的象限的动物偏见没有影响。因此，我们没有发现实验结果证明利诺吡丁作为认知增强剂的假设作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号