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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Effects of single and repeated electroconvulsive shock on isoproterenol-stimulated pineal N-acetyltransferase activity and melatonin production in rats.
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Effects of single and repeated electroconvulsive shock on isoproterenol-stimulated pineal N-acetyltransferase activity and melatonin production in rats.

机译：一次和多次电惊厥性休克对异丙肾上腺素刺激的松果体N-乙酰基转移酶活性和褪黑激素产生的影响。

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摘要

The response of the pineal gland to acute isoproterenol administration represents a useful tool to investigate beta 1-adrenoceptor function, because the production of melatonin and the activity of its main synthesizing enzyme, N-acetyltransferase (NAT), are regulated by beta 1-adrenergic receptors. In the present study, rats underwent single electroconvulsive shock (ECS) administration (0.80 mA, 0.5 s, at midday), chronic ECS treatment (0.80 mA, 0.5 s, once daily for 8 days), or sham treatments. On the day after the last ECS or sham ECS, animals were injected with isoproterenol hydrochloride (1 mg.kg-1 SC) or volume-matched saline at 1600 h. After single ECS, isoproterenol injection induced a clear-cut increase in both pineal NAT activity and melatonin levels with no significant differences between ECS-treated rats and the sham-treated ones. In rats chronically treated with ECS, the isoproterenol-induced increases in both pineal NAT activity and melatonin content were significantly lower than in sham-treated animals (p < 0.001 for NAT activity; p < 0.005 for melatonin levels; Turkey's test). These data show that the pinealocyte beta-adrenoceptor function is reduced by chronic, but not acute ECS administration, and that this change is not due to the nonspecific stress effect of animal handling or to the acute effects of the last of a series of ECS.
机译：松果体对急性异丙肾上腺素的反应是研究β1-肾上腺素受体功能的有用工具，因为褪黑激素的产生及其主要合成酶N-乙酰基转移酶（NAT）的活性受β1-肾上腺素能的调节。受体。在本研究中，大鼠接受单次电痉挛性休克（ECS）管理（0.80 mA，0.5 s，在中午），慢性ECS治疗（0.80 mA，0.5 s，每天一次，共8天）或假治疗。在最后一次ECS或假ECS的第二天，在1600 h给动物注射盐酸异丙肾上腺素（1 mg.kg-1 SC）或体积匹配的盐水。单次ECS注射后，异丙肾上腺素注射引起松果体NAT活性和褪黑激素水平明显增加，在ECS治疗的大鼠和假治疗的大鼠之间没有显着差异。在长期接受ECS治疗的大鼠中，异丙肾上腺素诱导的松果体NAT活性和褪黑激素含量的增加均显着低于假手术处理的动物（NAT活性p <0.001;褪黑激素水平p <0.005;土耳其检验）。这些数据表明，长期（而非急性）ECS给药会降低松果体细胞的β-肾上腺素受体功能，并且这种变化不是由于动物处理的非特异性应激作用或一系列ECS的最后一个的急性作用所致。

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