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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Effect of lipid-derived second messengers on electrophysiological taste responses in the gerbil.
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Effect of lipid-derived second messengers on electrophysiological taste responses in the gerbil.

机译：脂类第二信使对沙鼠电生理味觉反应的影响。

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摘要

Integrated chorda tympani (CT) recordings were made to salty, sour, sweet, bitter, and glutamate tastants before and after a 4-min application of modulators of lipid-derived second messenger systems. The modulators included two membrane-permeable analogues of DAG, 1-oleoyl-2-acetyl glycerol (OAG) and dioctanoyl glycerol (DiC8); thapsigargin, which releases Ca++ from intracellular stores; ionomycin, a calcium ionophore; lanthanum chloride, an inorganic calcium channel blocker; nifedipine, a dihydropyridine calcium channel blocker; quinacrine diHCl, a phospholipase A2 antagonist; melittin, a phospholipase A2 agonist; and indomethacin, which decreases the release of prostaglandins by inhibiting the enzyme cyclo-oxygenase. The main findings were: OAG (125 microM) and DiC8 (100 microM) blocked the responses of several bitter compounds while enhancing the taste response to several sweeteners. Lanthanum chloride blocked all responses, which may be due to the fact that it blocks tight junctions. Quinacrine (1 mM) suppressed several bitter responses while enhancing the response to several sweeteners. The enhancement of sweet taste responses by DAG analogues suggests that there is cross-talk between the adenylate cyclase system and one (or more) pathways involving lipid-derived second messengers in taste cells.
机译：在应用脂质衍生的第二信使系统调节剂4分钟之前和之后，对咸味，酸味，甜味，苦味和谷氨酸味的味觉进行了综合性的鼓膜鼓胃（CT）录音。调节剂包括DAG的两种膜可渗透的类似物：1-油酰基-2-乙酰基甘油（OAG）和二辛酰基甘油（DiC8）; thapsigargin，从细胞内储存中释放Ca ++;离子霉素，钙离子载体;氯化镧，一种无机钙通道阻滞剂;硝苯地平，一种二氢吡啶类钙通道阻滞剂;奎纳克林二盐酸盐，磷脂酶A2拮抗剂;蜂毒肽，磷脂酶A2激动剂;吲哚美辛，可通过抑制环加氧酶减少前列腺素的释放。主要发现是：OAG（125 microM）和DiC8（100 microM）阻止了几种苦味化合物的响应，同时增强了对几种甜味剂的味觉响应。氯化镧阻止了所有响应，这可能是由于它阻止了紧密的连接。奎纳克林（1 mM）抑制了几种苦味，同时增强了对几种甜味剂的反应。 DAG类似物增强了甜味响应，这表明腺苷酸环化酶系统与涉及味觉细胞中脂质衍生的第二信使的一个（或多个）途径之间存在串扰。

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