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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Inhibition of nitric oxide synthesis attenuates alcohol consumption in two strains of alcohol-preferring rats.
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Inhibition of nitric oxide synthesis attenuates alcohol consumption in two strains of alcohol-preferring rats.

机译：一氧化氮合成的抑制作用减弱了两种品系偏好酒精的大鼠的酒精消耗。

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摘要

The effect of the nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester (L-NAME) on voluntary alcohol consumption was examined in two different strains of alcohol-preferring rats, in a continuous-access, two-bottle-choice paradigm. Compared with the vehicle, intraperitoneal injections of L-NAME significantly and dose-dependently (10, 30, and 60 mg/kg) suppressed alcohol intake and preference in both alcohol-preferring (P) and Fawn-Hooded (FH) rats. The effect of the highest dose of L-NAME was nonspecific; it caused general decreases in consumption of alcohol, water, and food. Repeated injection of L-NAME (30 mg/kg) for 4 consecutive days significantly attenuated alcohol intake, but tolerance developed after 3 days of treatment. A single administration of a high dose of L-NAME (60 mg/kg) did not influence the blood alcohol concentrations, which suggests a possible central effect. Furthermore, a moderate dose of 30 mg/kg L-NAME, which selectively inhibited alcohol intake, did not exert a significant effect on telemetrically measured heart rate, core body temperature, and gross motor activity of alcohol naive Fawn-Hooded rats. These results suggest an involvement of nitric oxide in alcohol drinking behavior. Although the true mechanism(s) of action is not yet clear, it can be speculated that L-NAME may exert its action indirectly by modulating neurotransmitters proposed to be involved in alcohol drinking and/or by influencing other neuronal factors, such as neuronal Ca2+ channels, which have been shown to be involved in alcohol drinking behavior.
机译：一氧化氮合酶抑制剂NG-硝基-L-精氨酸甲酯（L-NAME）对自愿饮酒的影响在连续使用，两瓶选择范式的两种不同品系的偏爱酒精的大鼠中进行了研究。与赋形剂相比，腹膜内注射L-NAME显着且剂量依赖性（10、30和60 mg / kg）抑制了偏爱酒精的（P）和Fawn-Hooded（FH）大鼠的酒精摄入和偏爱。最高剂量的L-NAME的作用是非特异性的;它导致酒精，水和食物的消耗量普遍下降。连续4天重复注射L-NAME（30 mg / kg）会明显减少酒精摄入，但治疗3天后出现耐受性。一次高剂量L-NAME（60 mg / kg）的单次给药不会影响血液中的酒精浓度，这表明可能产生中枢作用。此外，选择性抑制酒精摄入的中等剂量的30 mg / kg L-NAME对遥测酒精的Fawn-Hooded大鼠的心率，核心体温和总运动活动没有显着影响。这些结果表明一氧化氮参与饮酒行为。尽管尚不清楚确切的作用机制，但可以推测L-NAME可能通过调节拟与饮酒有关的神经递质和/或通过影响其他神经元因素（例如神经元Ca2 +）间接发挥作用。渠道，这些渠道已被证明与饮酒行为有关。

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