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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Effect of administration of angiotensin II and isoproterenol, alone and in combination, on drinking and tail skin temperature of the rat.
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Effect of administration of angiotensin II and isoproterenol, alone and in combination, on drinking and tail skin temperature of the rat.

机译：单独或组合使用血管紧张素II和异丙肾上腺素对大鼠饮酒和尾巴皮肤温度的影响。

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摘要

Both angiotensin II (AII) and the beta-adrenergic agonist isoproterenol are well known to induce drinking and increase tail skin temperature (TSK) in rats. Previous studies have shown that these two compounds have an additive, rather than interactive, dipsogenic effect when administered together. The present studies confirmed the additivity of the dipsogenic effect of the two compounds and attempted to extend these results to TSK. The results reveal that at a series of dosage combinations of AII [100 and 125 micrograms/kg, subcutaneously (SC)] and isoproterenol (ISOP) (10, 12.5, and 25 micrograms/kg, SC) administered together, the increase in TSK usually induced by each compound was canceled. This occurred at the lower doses of ISOP in combination with AII. Thus, the differences between dipsogenic and thermoregulatory effects of combined doses of AII and ISOP suggest a difference in central integration. Important differences between the thermoregulatory responses to administration of the two compounds include increases in metabolic rate and colonic temperature when ISOP is administered and decreases in both when AII is administered. It is suggested that the effect of the two compounds to cancel each other with respect to TSK is related to their opposite effects on metabolic rate.
机译：众所周知，血管紧张素II（AII）和β-肾上腺素能激动剂异丙肾上腺素都可诱导大鼠饮酒并增加尾部皮肤温度（TSK）。先前的研究表明，这两种化合物一起给药时具有加成作用，而不是相互作用的成岩作用。目前的研究证实了这两种化合物的成岩作用的可加性，并试图将这些结果扩展到TSK。结果表明，在一系列AII [皮下（SC）100和125微克/千克和异丙肾上腺素（ISOP）（10、12.5和25微克/千克，SC）的剂量组合下，TSK升高通常由每种化合物诱导被抵消。这是在较低剂量的ISOP与AII结合时发生的。因此，AII和ISOP的联合剂量在浸没和温度调节作用之间的差异表明中央整合的差异。两种化合物给药的温度调节反应之间的重要差异包括：给药ISOP时代谢率和结肠温度升高，而给药AII时两者均降低。建议这两种化合物相对于TSK相互抵消的作用与其对代谢率的相反作用有关。

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